SCTR and ADCYAP1

Number of citations of the paper that reports this interaction (PubMedID 1335692)
0

Data Source:
BioGRID (unspecified method, unspecified method)
HPRD (in vivo, in vitro)

		SCTR	ADCYAP1
Description		secretin receptor	adenylate cyclase activating polypeptide 1
Image
GO Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Neuron Projection Perikaryon
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Nervous System Development Female Pregnancy Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Insulin Secretion Neuron Projection Development Regulation Of Protein Localization Positive Regulation Of GTPase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Growth Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs		Secretin human	2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS		Bipolar disorder ( 31043756) Type 2 diabetes ( 30718926 32499647)	Body size at age 10 ( 32376654) Chronotype ( 30696823) Midgestational cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Pancreas volume ( 34128465) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1	9 interacting genes: ADCYAP1R1 CASP2 CFTR CPAMD8 MME SCTR SHH VIPR1 VIPR2
Entrez ID		6344	116
HPRD ID		01628	02369
Ensembl ID		ENSG00000080293	ENSG00000141433
Uniprot IDs		P47872 Q8IV17	B7Z222 P18509
PDB IDs		6WI9 6WZG 7D3S	1GEA 2D2P 2JOD 6LPB 6M1I 6P9Y 6VN7 7VQX 7WBJ 8E3X 8E3Y
Enriched GO Terms of Interacting Partners?		Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Peptide Hormone Binding G Protein-coupled Peptide Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Protein Processing Cell Surface Receptor Signaling Pathway Plasma Membrane Negative Regulation Of Response To Reactive Oxygen Species G Protein-coupled Receptor Signaling Pathway Cell Surface Protein Maturation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Neuropeptide Processing Secretin Receptor Activity Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Left Lung Development Positive Regulation Of Sclerotome Development Right Lung Development Polarity Specification Of Anterior/posterior Axis Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Primary Prostatic Bud Elongation Tracheoesophageal Septum Formation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Odontogenesis Of Dentin-containing Tooth Developmental Process Involved In Reproduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Anion Channel Activity Endopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Peptidase Activity Endopeptidase Complex Odontogenesis Positive Regulation Of Monoatomic Anion Transport Lung Development Substance P Catabolic Process Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
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