SARS and TINF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		SARS	TINF2
Gene Name		seryl-tRNA synthetase	TERF1 (TRF1)-interacting nuclear factor 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	RNA Binding Serine-tRNA Ligase Activity ATP Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Seryl-tRNA Aminoacylation TRNA Processing Gene Expression Selenocysteinyl-tRNA(Sec) Biosynthetic Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		L-Serine
Diseases
GWAS
Protein-Protein Interactions		4 interactors: POT1 TERF1 TINF2 TRS-AGA2-4	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		6301	26277
HPRD ID		09605	16056
Ensembl ID		ENSG00000031698	ENSG00000092330
Uniprot IDs		P49591 Q0VGA5	B4DFJ1 Q9BSI4
PDB IDs		3VBB 4L87	3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Telomere Assembly Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Telomerase Activity RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Regulation Of Organelle Organization Chromosome Organization DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of Biosynthetic Process Homeostatic Process Regulation Of Protein ADP-ribosylation Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening DNA Replication Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Negative Regulation Of Transferase Activity Cellular Component Assembly Regulation Of Cellular Component Organization Positive Regulation Of Helicase Activity Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Protein Glycosylation Negative Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Microtubule Polymerization	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		acutely adapting atrial attenuates concluded congestion damaged destruction elevations increments intact lap laps left maintained mitral mmhg operated potentials pulmonary rabbits raised rars respond sham slowly valve venous ventricular	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		acutely adapting atrial attenuates concluded congestion damaged destruction elevations increments intact lap laps left maintained mitral mmhg operated potentials pulmonary rabbits raised rars respond sham slowly valve venous ventricular	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?