SARS1

Name	seryl-tRNA synthetase 1
Structure
Novel Interactors	1 novel interactors: PTPN22
Interactors	6 interactors: LINC01554 POT1 SUMO2 TERF1 TINF2 TRS-AGA2-3
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	TRNA Binding Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Aminoacyl-tRNA Ligase Activity Serine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Molecular Adaptor Activity Selenocysteine-tRNA Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Selenocysteine Incorporation Cytoplasmic Translation TRNA Modification Translation TRNA Aminoacylation For Protein Translation Seryl-tRNA Aminoacylation Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production
Pathways	Selenocysteine synthesis Cytosolic tRNA aminoacylation
Drugs	Serine
GWAS	No GWAS studies recorded
Entrez ID	6301
HPRD ID	09605
Ensembl ID	ENSG00000031698
Uniprot IDs	P49591 Q0VGA5 Q5T5C7
PDB IDs	3VBB 4L87 4RQE 4RQF 8P7B 8P7C 8P7D
GO Terms Enriched among Interactors ?	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly Telomere Maintenance G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Phosphoanandamide Dephosphorylation Positive Regulation Of Cellular Component Organization DNA Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Positive Regulation Of Organelle Organization 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Chromosome