SARS1 and LINC01554

Number of citations of the paper that reports this interaction (PubMedID 30809309)
42

Data Source:
BioGRID (unspecified method)

		SARS1	LINC01554
Description		seryl-tRNA synthetase 1	long intergenic non-protein coding RNA 1554
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	TRNA Binding Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Aminoacyl-tRNA Ligase Activity Serine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Molecular Adaptor Activity Selenocysteine-tRNA Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Selenocysteine Incorporation Cytoplasmic Translation TRNA Modification Translation TRNA Aminoacylation For Protein Translation Seryl-tRNA Aminoacylation Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production
Pathways		Selenocysteine synthesis Cytosolic tRNA aminoacylation
Drugs		Serine
Diseases
GWAS			LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		6 interacting genes: LINC01554 POT1 SUMO2 TERF1 TINF2 TRS-AGA2-3	141 interacting genes: AARS1 ACADVL ACIN1 ACTB ACTG1 ACTN1 ACTN3 ACTR3 ALDOA ANXA2 ANXA5 ANXA6 APEX1 ARHGAP1 ASS1 ATAD3A ATIC ATP5F1A BZW2 CANX CCT2 CCT3 CCT4 CCT6A CCT7 CKAP4 CS CTPS1 DDX3X DDX46 DHX9 DNAH2 DNAJA1 DST DYNC1H1 EDARADD EEF1G EEF2 EIF3A EIF3E EIF4A2 EIF4B ENO1 ENO3 EPRS1 ERO1A G3BP1 G6PD GANAB GAPDH GARS1 GDI2 GPI GTF2I HIVEP2 HMCN1 HNRNPF HSP90AA1 HSP90B1 HSPA1L HSPA5 HSPA8 HSPA9 HSPD1 HYOU1 IDH1 IPO4 IPO7 IPO9 ITPR2 KARS1 KPNA1 KPNB1 KRT18 KRT7 KRT8 KRT8P3 LRPPRC MCM7 MSN MYO18A NAP1L1 NAP1L4 NCBP1 NCL NPM1 OLA1 OXCT1 PABPC1 PCBP2 PDIA3 PDIA6 PFAS PGD PGK1 PGM1 PHGDH PKM PLOD2 PMPCA POR PPP2R1A PSMC1 PSMD2 PSMD7 PTBP1 RDX RPL6 RPSA RTCB RTN4 SARS1 SEPTIN7 SEPTIN9 SERPINH1 SFPQ SQSTM1 TARS1 TGFBI THOP1 TKT TTF2 TUBA1A TUBA8 TUBB TUBB2A TUBB3 TUBB4A TUBB4B TUBB6 TUFM TXNRD1 TYMP UBA1 VCL VCP VIM VPS35 WARS1 XPO1 XRCC5
Entrez ID		6301	202299
HPRD ID		09605	16896
Ensembl ID		ENSG00000031698	ENSG00000236882
Uniprot IDs		P49591 Q0VGA5 Q5T5C7
PDB IDs		3VBB 4L87 4RQE 4RQF 8P7B 8P7C 8P7D
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomeric D-loop Disassembly Telomere Maintenance G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Phosphoanandamide Dephosphorylation Positive Regulation Of Cellular Component Organization DNA Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Positive Regulation Of Organelle Organization 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Chromosome	Extracellular Exosome RNA Binding Nucleotide Binding Cytosol Cytoplasm Unfolded Protein Binding ATP-dependent Protein Folding Chaperone ATP Hydrolysis Activity ATP Binding Focal Adhesion Protein Folding Secretory Granule Lumen Cadherin Binding Ficolin-1-rich Granule Lumen Protein Folding Chaperone Structural Constituent Of Cytoskeleton Nucleotide Metabolic Process Nicotinamide Nucleotide Metabolic Process Microtubule Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process Ligase Activity Melanosome Purine Nucleotide Metabolic Process Nucleoside Phosphate Metabolic Process Protein Refolding Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Positive Regulation Of Telomerase RNA Localization To Cajal Body Ribose Phosphate Metabolic Process ADP Catabolic Process Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex ATP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoprotein Complex Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleotide Catabolic Process Nucleoside Diphosphate Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Ribonucleotide Metabolic Process Microtubule Cytoskeleton Protein Folding In Endoplasmic Reticulum Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Nucleobase-containing Compound Catabolic Process Translation TRNA Aminoacylation
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