IL15 and TRAF3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL15	TRAF3
Gene Name		interleukin 15	TNF receptor-associated factor 3
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Integral Component Of Plasma Membrane Cell Surface Membrane	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Natural Killer Cell Differentiation NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cellular Response To Vitamin D	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus
Pathways			Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Response to treatment for acute lymphoblastic leukemia ( 19176441)	Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		7 interactors: APP IL15RA IL2RB IL2RG STAT5B TRAF3 ZNRD1	55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11
Entrez ID		3600	7187
HPRD ID		02776	03539
Ensembl ID		ENSG00000164136	ENSG00000131323
Uniprot IDs		P40933 Q6FGX7	A6NHG8 Q13114
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?		Response To Interleukin-2 Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interleukin-2-mediated Signaling Pathway Response To Cytokine Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Interleukin-4 Response To Organic Substance Regulation Of Multicellular Organism Growth Positive Regulation Of Mitotic Cell Cycle Interleukin-7-mediated Signaling Pathway Synaptic Growth At Neuromuscular Junction Signal Transduction Collateral Sprouting In Absence Of Injury Signaling Cell Communication Creatinine Metabolic Process Development Of Secondary Male Sexual Characteristics Positive Regulation Of Innate Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Isoleucine Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Allantoin Metabolic Process Positive Regulation Of Natural Killer Cell Proliferation Immune System Process Taurine Metabolic Process Axon Choice Point Recognition Regulation Of Natural Killer Cell Proliferation Regulation Of Innate Immune Response Prolactin Signaling Pathway Response To Interleukin-15 Steroid Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Stimulus Negative Regulation Of Erythrocyte Differentiation Valine Metabolic Process Neuron Remodeling Creatine Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Gamma-delta T Cell Activation Succinate Metabolic Process Development Of Secondary Female Sexual Characteristics Regulation Of Developmental Growth Toll Signaling Pathway Positive Regulation Of Natural Killer Cell Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics	Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death
Tagcloud ?		125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Difference) ?		125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Intersection) ?