IL15 and STAT5B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL15	STAT5B
Gene Name		interleukin 15	signal transducer and activator of transcription 5B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Integral Component Of Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Natural Killer Cell Differentiation NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cellular Response To Vitamin D	Allantoin Metabolic Process Luteinization Response To Hypoxia Natural Killer Cell Differentiation Liver Development Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Acute-phase Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus
Pathways			Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs			Dasatinib
Diseases
GWAS		Response to treatment for acute lymphoblastic leukemia ( 19176441)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: APP IL15RA IL2RB IL2RG STAT5B TRAF3 ZNRD1	49 interactors: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		3600	6777
HPRD ID		02776	05037
Ensembl ID		ENSG00000164136	ENSG00000173757
Uniprot IDs		P40933 Q6FGX7	P51692
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Response To Interleukin-2 Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interleukin-2-mediated Signaling Pathway Response To Cytokine Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Interleukin-4 Response To Organic Substance Regulation Of Multicellular Organism Growth Positive Regulation Of Mitotic Cell Cycle Interleukin-7-mediated Signaling Pathway Synaptic Growth At Neuromuscular Junction Signal Transduction Collateral Sprouting In Absence Of Injury Signaling Cell Communication Creatinine Metabolic Process Development Of Secondary Male Sexual Characteristics Positive Regulation Of Innate Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Isoleucine Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Allantoin Metabolic Process Positive Regulation Of Natural Killer Cell Proliferation Immune System Process Taurine Metabolic Process Axon Choice Point Recognition Regulation Of Natural Killer Cell Proliferation Regulation Of Innate Immune Response Prolactin Signaling Pathway Response To Interleukin-15 Steroid Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Stimulus Negative Regulation Of Erythrocyte Differentiation Valine Metabolic Process Neuron Remodeling Creatine Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Gamma-delta T Cell Activation Succinate Metabolic Process Development Of Secondary Female Sexual Characteristics Regulation Of Developmental Growth Toll Signaling Pathway Positive Regulation Of Natural Killer Cell Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics	Cellular Response To Organic Substance Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Hormone Regulation Of MAPK Cascade Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Response To Cytokine Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Phosphorylation Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Cellular Response To Growth Hormone Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Signaling Regulation Of Phosphorus Metabolic Process Signal Transduction JAK-STAT Cascade Positive Regulation Of MAPK Cascade Defense Response Cell Communication Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Immune System Process Cellular Response To Cytokine Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Response To Peptide Hormone Positive Regulation Of Transferase Activity Innate Immune Response
Tagcloud ?		125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Difference) ?		125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Intersection) ?