IL15 and IL2RB

Number of citations of the paper that reports this interaction (PubMedID 8026467)
39

Data Source:
HPRD (in vivo)

		IL15	IL2RB
Description		interleukin 15	interleukin 2 receptor subunit beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Nuclear Speck	Endosome Cytosol Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Protein Binding Coreceptor Activity Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Positive Regulation Of Cytokine Production NK T Cell Proliferation Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Negative Regulation Of Cold-induced Thermogenesis	Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly
Pathways		Interleukin-15 signaling Interleukin-15 signaling	RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		Cefazolin	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Asthma ( 20860503 32296059) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)
Interacting Genes		9 interacting genes: APP IL15RA IL2RB IL2RG POLR1H S100A6 S100P STAT5B TRAF3	29 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MTDH PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK TRIP13
Entrez ID		3600	3560
HPRD ID		02776	00896
Ensembl ID		ENSG00000164136	ENSG00000100385
Uniprot IDs		P40933	P14784
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7	2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K 7S2S
Enriched GO Terms of Interacting Partners?		Interleukin-15 Receptor Activity Interleukin-15-mediated Signaling Pathway Positive Regulation Of Endocytosis Interleukin-2 Binding Interleukin-2 Receptor Activity Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Phagocytosis Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Endocytosis Endosome Interleukin-2-mediated Signaling Pathway Regulation Of Phagocytosis Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell Activation Transition Metal Ion Binding Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of B Cell Differentiation Natural Killer Cell Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Vesicle-mediated Transport Immune System Process Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of B Cell Differentiation Immune Response Regulation Of Lymphocyte Differentiation Cell Surface Regulation Of Cell Activation Cell Activation T Cell Differentiation In Thymus Lymphocyte Differentiation Regulation Of Natural Killer Cell Activation Protein Homodimerization Activity Natural Killer Cell Activation Coreceptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Mononuclear Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transport Positive Regulation Of Lymphocyte Activation Regulation Of Immune System Process External Side Of Plasma Membrane	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Hemopoiesis Lymphocyte Activation Regulation Of Multicellular Organismal Development Interleukin-15-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Leukocyte Activation Regulation Of Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Interleukin-2-mediated Signaling Pathway Regulation Of Lymphocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Lymphocyte Activation Cell Activation Positive Regulation Of Lymphocyte Differentiation Interleukin-9-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Cell Adhesion Cell Differentiation Mononuclear Cell Differentiation Regulation Of Cell Development Growth Hormone Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of T Cell Differentiation Positive Regulation Of Leukocyte Differentiation Leukocyte Differentiation Regulation Of Multicellular Organismal Process T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Signal Transduction Lymphocyte Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Proliferation Cellular Developmental Process Mononuclear Cell Proliferation Positive Regulation Of T Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Cell Differentiation Activated T Cell Proliferation
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