IL15 and POLR1H

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IL15	POLR1H
Description		interleukin 15	RNA polymerase I subunit H
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Nuclear Speck	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	Nucleic Acid Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Positive Regulation Of Cytokine Production NK T Cell Proliferation Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Negative Regulation Of Cold-induced Thermogenesis	Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination Of RNA Polymerase I Transcription
Pathways		Interleukin-15 signaling Interleukin-15 signaling	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs		Cefazolin
Diseases
GWAS		Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		9 interacting genes: APP IL15RA IL2RB IL2RG POLR1H S100A6 S100P STAT5B TRAF3	18 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 TRIML2 UBE2I ZNF593
Entrez ID		3600	30834
HPRD ID		02776	09601
Ensembl ID		ENSG00000164136	ENSG00000066379
Uniprot IDs		P40933	Q2L6J2 Q9P1U0
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7	7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Interleukin-15 Receptor Activity Interleukin-15-mediated Signaling Pathway Positive Regulation Of Endocytosis Interleukin-2 Binding Interleukin-2 Receptor Activity Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Phagocytosis Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Endocytosis Endosome Interleukin-2-mediated Signaling Pathway Regulation Of Phagocytosis Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell Activation Transition Metal Ion Binding Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of B Cell Differentiation Natural Killer Cell Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Vesicle-mediated Transport Immune System Process Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of B Cell Differentiation Immune Response Regulation Of Lymphocyte Differentiation Cell Surface Regulation Of Cell Activation Cell Activation T Cell Differentiation In Thymus Lymphocyte Differentiation Regulation Of Natural Killer Cell Activation Protein Homodimerization Activity Natural Killer Cell Activation Coreceptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Mononuclear Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transport Positive Regulation Of Lymphocyte Activation Regulation Of Immune System Process External Side Of Plasma Membrane
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