IL3

Description		interleukin 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling
Drugs		Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Novel Interacting Genes		5 novel interacting genes: BRD8 HSPA1A HSPA9 IRF1 PPP2CA
Interacting Genes		7 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD S100A6 S100P
Entrez ID		3562
HPRD ID		00987
Ensembl ID		ENSG00000164399
Uniprot IDs		P08700
PDB IDs		1JLI 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?		Interleukin-3 Receptor Activity Regulation Of Cell Population Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol 3-kinase Complex Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Signal Transduction T Cell Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune System Process Regulation Of Cytoskeleton Organization Cytokine Receptor Activity Adipose Tissue Development Regulation Of Cell Cycle Regulation Of Erythrocyte Differentiation Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Fibroblast Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein Folding Chaperone Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Microtubule Polymerization Adaptive Immune Response Perinuclear Region Of Cytoplasm Connective Tissue Development Interleukin-5 Receptor Activity Insulin Receptor Signaling Pathway GTPase Complex Denatured Protein Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
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