IL3 and IL3RA

Number of citations of the paper that reports this interaction (PMID 8649415)
8

Data Source:
HPRD (in vivo, in vitro)

		IL3	IL3RA
Gene Name		interleukin 3	interleukin 3 receptor, alpha (low affinity)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Interleukin-3 Receptor Activity
	Biological Process	Positive Regulation Of Myeloid Leukocyte Differentiation Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of DNA Replication Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation	Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Amlexanox	Sargramostim
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Inflammatory bowel disease ( 23128233)	Schizophrenia ( 17522711)
Protein-Protein Interactions		5 interactors: CSF2RB HRAS IL3RA PIK3CA PIK3CD	15 interactors: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2
Entrez ID		3562	3563
HPRD ID		00987	02392
Ensembl ID		ENSG00000164399	ENSG00000185291
Uniprot IDs		P08700	P26951
PDB IDs		1JLI
Enriched GO Terms of Interacting Partners?		Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phosphatidylinositol Phosphorylation Lipid Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Innate Immune Response Insulin Receptor Signaling Pathway Hypomethylation Of CpG Island Interleukin-5-mediated Signaling Pathway Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Negative Regulation Of Neuron Apoptotic Process Signal Transduction Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Glycerophospholipid Biosynthetic Process Lipid Modification Negative Regulation Of Neuron Death Signaling Neutrophil Extravasation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Mast Cell Chemotaxis Cellular Response To Insulin Stimulus Phosphatidylinositol Metabolic Process	Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of JAK-STAT Cascade Response To Organic Substance Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of DNA Replication Regulation Of Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Response To Lipopolysaccharide Cellular Response To Stimulus Response To Molecule Of Bacterial Origin Response To Stimulus Response To Cytokine Regulation Of Protein Import Into Nucleus, Translocation Regulation Of DNA Replication Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Lipid Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Macrophage Activation Regulation Of Phosphorus Metabolic Process Response To Toxic Substance Regulation Of Protein Metabolic Process Response To Bacterium Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Growth Hormone Histone Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Intracellular Signal Transduction
Tagcloud ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?