IL3 and IL3RA

Number of citations of the paper that reports this interaction (PubMedID 8649415)
56

Data Source:
HPRD (in vitro, in vivo)

		IL3	IL3RA
Description		interleukin 3	interleukin 3 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Sargramostim Tagraxofusp
Diseases
GWAS		Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Schizophrenia ( 17522711)
Interacting Genes		7 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD S100A6 S100P	32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5
Entrez ID		3562	3563
HPRD ID		00987	02392
Ensembl ID		ENSG00000164399	ENSG00000185291
Uniprot IDs		P08700	P26951
PDB IDs		1JLI 5UV8 5UWC 6NMY	4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?		Interleukin-3 Receptor Activity Regulation Of Cell Population Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol 3-kinase Complex Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Signal Transduction T Cell Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune System Process Regulation Of Cytoskeleton Organization Cytokine Receptor Activity Adipose Tissue Development Regulation Of Cell Cycle Regulation Of Erythrocyte Differentiation Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Fibroblast Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein Folding Chaperone Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Microtubule Polymerization Adaptive Immune Response Perinuclear Region Of Cytoplasm Connective Tissue Development Interleukin-5 Receptor Activity Insulin Receptor Signaling Pathway GTPase Complex Denatured Protein Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity	Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Organ Growth Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Interleukin-5-mediated Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Cellular Response To Interleukin-3 Positive Regulation Of Protein Transport Neutrophil Differentiation Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Regulation Of Protein Transport Ventricular Cardiac Muscle Cell Development Positive Regulation Of Protein Localization Growth Hormone Receptor Binding Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Protein Secretion Establishment Of Protein Localization To Plasma Membrane Mitotic Nuclear Membrane Disassembly Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Regulation Of Heart Growth Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Nuclear Membrane Disassembly Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Disassembly Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Establishment Of Protein Localization To Membrane Regulation Of Growth Positive Regulation Of Protein Localization To Nucleus Nuclear Envelope Organization Growth Hormone Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Circadian Rhythm Positive Regulation Of Cardiac Muscle Cell Proliferation Myeloid Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
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