IL3 and PIK3CD

Number of citations of the paper that reports this interaction (PMID 9113989)
73

Data Source:
HPRD (in vivo)

		IL3	PIK3CD
Gene Name		interleukin 3	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Mast Cell Granule
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Positive Regulation Of Myeloid Leukocyte Differentiation Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of DNA Replication Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation	Natural Killer Cell Differentiation B Cell Homeostasis Cytokine Production Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation T Cell Differentiation Neutrophil Chemotaxis Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Mast Cell Differentiation Neutrophil Extravasation
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs		Amlexanox
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: CSF2RB HRAS IL3RA PIK3CA PIK3CD	14 interactors: ASCC2 ERAS FAM195A HRAS IL3 IL4 IRS2 KITLG PIK3CG PIK3R1 PIK3R2 RALY TAGLN TNPO2
Entrez ID		3562	5293
HPRD ID		00987	04161
Ensembl ID		ENSG00000164399	ENSG00000171608
Uniprot IDs		P08700	A7E2E0 B7ZM44 O00329 Q5SR50
PDB IDs		1JLI
Enriched GO Terms of Interacting Partners?		Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phosphatidylinositol Phosphorylation Lipid Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Innate Immune Response Insulin Receptor Signaling Pathway Hypomethylation Of CpG Island Interleukin-5-mediated Signaling Pathway Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Negative Regulation Of Neuron Apoptotic Process Signal Transduction Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Glycerophospholipid Biosynthetic Process Lipid Modification Negative Regulation Of Neuron Death Signaling Neutrophil Extravasation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Mast Cell Chemotaxis Cellular Response To Insulin Stimulus Phosphatidylinositol Metabolic Process	Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Immune Response Regulation Of Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Fc Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of DNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Myeloid Cell Differentiation Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Positive Regulation Of Mast Cell Proliferation Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Migration Positive Regulation Of DNA Replication Negative Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Glucose Homeostasis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Insulin Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility
Tagcloud ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified
Tagcloud (Difference) ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified
Tagcloud (Intersection) ?