IL3 and CSF2RB

Number of citations of the paper that reports this interaction (PMID 9278420)
1

Data Source:
HPRD (in vivo, in vitro)

		IL3	CSF2RB
Gene Name		interleukin 3	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding
	Biological Process	Positive Regulation Of Myeloid Leukocyte Differentiation Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of DNA Replication Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation	Signal Transduction Respiratory Gaseous Exchange Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Amlexanox
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: CSF2RB HRAS IL3RA PIK3CA PIK3CD	27 interactors: CISH CSF2 CSF2RA EPOR FES FYN GNB2L1 HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 SHC1 STAT1 STAT3 SYK YWHAZ
Entrez ID		3562	1439
HPRD ID		00987	00739
Ensembl ID		ENSG00000164399	ENSG00000100368
Uniprot IDs		P08700	B4DZL8 P32927 Q6NSJ8
PDB IDs		1JLI	1C8P 1EGJ 1GH7 2GYS 3CXE
Enriched GO Terms of Interacting Partners?		Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phosphatidylinositol Phosphorylation Lipid Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Innate Immune Response Insulin Receptor Signaling Pathway Hypomethylation Of CpG Island Interleukin-5-mediated Signaling Pathway Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Negative Regulation Of Neuron Apoptotic Process Signal Transduction Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Glycerophospholipid Biosynthetic Process Lipid Modification Negative Regulation Of Neuron Death Signaling Neutrophil Extravasation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Mast Cell Chemotaxis Cellular Response To Insulin Stimulus Phosphatidylinositol Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Organic Substance Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Immune Response Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Response To Cytokine Immune System Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Defense Response Regulation Of Immune Response Cellular Response To Peptide Hormone Stimulus Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Innate Immune Response Regulation Of Immune System Process Regulation Of JAK-STAT Cascade Regulation Of Signal Transduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Signal Transduction Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Intracellular Signal Transduction Regulation Of Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cell Migration Signaling Response To Peptide Cell Communication Leukocyte Migration Cellular Response To Stimulus Cell Motility Response To Growth Hormone Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Amino Acid Metabolic Process Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Tagcloud ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133
Tagcloud (Difference) ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133
Tagcloud (Intersection) ?