IL3 and PIK3CA

Number of citations of the paper that reports this interaction (PMID 9113989)
73

Data Source:
HPRD (in vitro)

		IL3	PIK3CA
Gene Name		interleukin 3	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Lamellipodium
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Positive Regulation Of Myeloid Leukocyte Differentiation Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of DNA Replication Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation	Angiogenesis Vasculature Development Glucose Metabolic Process Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of Peptidyl-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Multicellular Organism Growth Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Hypomethylation Of CpG Island Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Cardiac Muscle Contraction Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Genetic Imprinting Negative Regulation Of Anoikis
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by Interleukins Signaling by VEGF Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade
Drugs		Amlexanox
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: CSF2RB HRAS IL3RA PIK3CA PIK3CD	43 interactors: ADAP1 AMBP APLP2 APPL1 ATPIF1 ATR DDX5 DNAJB6 FASLG FTL GABRB1 GNAQ GRIN2B HRAS IL3 IRS2 IRS4 ITIH1 KRAS LCK MRAS NEDD9 NRAS PDE4D PDGFRB PIK3R1 PIK3R3 PRKCD RASD2 RASGRP3 RPS20 RPS6KB1 SGK1 SH3KBP1 SLC9A3R1 SLC9A3R2 SMAD2 SMAD3 SQSTM1 STAT1 TICAM1 UFD1L VARS2
Entrez ID		3562	5290
HPRD ID		00987	01382
Ensembl ID		ENSG00000164399
Uniprot IDs		P08700	P42336
PDB IDs		1JLI	2ENQ 2RD0 3HHM 3HIZ 3ZIM
Enriched GO Terms of Interacting Partners?		Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phosphatidylinositol Phosphorylation Lipid Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Innate Immune Response Insulin Receptor Signaling Pathway Hypomethylation Of CpG Island Interleukin-5-mediated Signaling Pathway Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Negative Regulation Of Neuron Apoptotic Process Signal Transduction Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Glycerophospholipid Biosynthetic Process Lipid Modification Negative Regulation Of Neuron Death Signaling Neutrophil Extravasation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Mast Cell Chemotaxis Cellular Response To Insulin Stimulus Phosphatidylinositol Metabolic Process	Regulation Of Signal Transduction Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Intracellular Signal Transduction Cell Communication Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Insulin Stimulus Cellular Response To Peptide Hormone Stimulus Insulin Receptor Signaling Pathway Cellular Response To Peptide Regulation Of Catalytic Activity Cellular Response To Organic Substance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Growth Factor Regulation Of Phosphorylation Response To Organic Substance Regulation Of Cell Death Apoptotic Process Response To Insulin Intracellular Signal Transduction Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Cell Death Death Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Peptide Hormone Fibroblast Growth Factor Receptor Signaling Pathway Response To Peptide Regulation Of Metabolic Process Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cellular Process Response To Fibroblast Growth Factor Regulation Of Immune Response Response To Stimulus Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway
Tagcloud ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl next recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	amplified biomarker e542k e545d e545k embedded fixed formalin h1047l h1047r homolog metastatic namely next oncogenic paraffin phospho phosphoinositol pi3k pras40thr246 proline pten reflect refractory respond retrospectively tensin trastuzumab unlikely
Tagcloud (Difference) ?		absolutely affects colony continuous csf elicited erythroleukemia gain gm granulocyte hemopoietic insight macrophage mpl recruitment sets sh2 shared shc stat5 stimulating talk tf tpo transduction tyrosine versa vice	amplified biomarker e542k e545d e545k embedded fixed formalin h1047l h1047r homolog metastatic namely oncogenic paraffin phospho phosphoinositol pi3k pras40thr246 proline pten reflect refractory respond retrospectively tensin trastuzumab unlikely
Tagcloud (Intersection) ?		next