ITPR1 and TRPC4

Number of citations of the paper that reports this interaction (PubMedID 11163362)
0

Data Source:
HPRD (two hybrid, in vitro)

		ITPR1	TRPC4
Description		inositol 1,4,5-trisphosphate receptor type 1	transient receptor potential cation channel subfamily C member 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse	Plasma Membrane Caveola Cell-cell Junction Cell Surface Membrane Basolateral Plasma Membrane Cortical Cytoskeleton Protein-containing Complex Cation Channel Complex Calcium Channel Complex Membrane Raft
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Calcium Channel Inhibitor Activity Protein Domain Specific Binding Phosphatidylinositol Binding Protein Homodimerization Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Apoptotic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Single Fertilization Post-embryonic Development Regulation Of Autophagy Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Import Into The Mitochondrion Epithelial Fluid Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Ligand-gated Ion Channel Signaling Pathway	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Secretion Monoatomic Ion Transmembrane Transport Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TRP channels Role of second messengers in netrin-1 signaling
Drugs		Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32154731 32203549) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)	Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 NHERF1 TJP1 TRPC1 TRPC5
Entrez ID		3708	7223
HPRD ID		00925	09154
Ensembl ID		ENSG00000150995	ENSG00000133107
Uniprot IDs		B4DER3 B4DGH1 Q14643 Q59H91	Q9UBN4
PDB IDs			8WPL 8WPM 8WPN
Enriched GO Terms of Interacting Partners?		Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Intracellular Signal Transduction Signal Transduction G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Transport Regulation Of Cell Communication Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling G Protein-coupled Glutamate Receptor Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle System Process Glutamate Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Protein Phosphorylation Response To Calcium Ion Calcium Ion Transport Phosphorylation Regulation Of Monoatomic Cation Transmembrane Transport Plasma Membrane Negative Regulation Of Signal Transduction Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Multicellular Organismal Process Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Hydrogen Peroxide Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Transport Regulation Of Store-operated Calcium Entry Regulation Of Cell Activation Negative Regulation Of Apoptotic Process Lymphocyte Proliferation Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Calcium Ion Homeostasis Mononuclear Cell Proliferation Protein Kinase Activity	Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Ion Transmembrane Transport Calcium Channel Activity Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Metal Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Monoatomic Ion Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Cation Transport Inorganic Ion Homeostasis Calcium Ion Homeostasis Monoatomic Ion Transport Calcium Ion Transmembrane Import Into Cytosol Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Homeostatic Process Monoatomic Ion Transmembrane Transport Plasma Membrane Chemical Homeostasis Intracellular Calcium Ion Homeostasis Transport Vesicle Membrane Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Intracellular Chemical Homeostasis Sarcoplasmic Reticulum Phospholipase C-activating Dopamine Receptor Signaling Pathway Store-operated Calcium Channel Activity Apical Part Of Cell Cellular Homeostasis Calcium Ion Transmembrane Transporter Activity Secretory Granule Membrane Phosphatidylinositol Binding Cellular Response To Ethanol G Protein-coupled Receptor Signaling Pathway Cation Channel Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Membrane Acid Secretion Calcium-mediated Signaling Receptor Complex
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