ITPR1 and HOMER1

Number of citations of the paper that reports this interaction (PMID 9808459)
116

Data Source:
HPRD (in vivo, in vitro)

		ITPR1	HOMER1
Gene Name		inositol 1,4,5-trisphosphate receptor, type 1	homer homolog 1 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane	Z Disc Cell Junction Axon Neuronal Cell Body Costamere Dendritic Shaft Apical Part Of Cell Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding	Type 5 Metabotropic Glutamate Receptor Binding Protein Complex Scaffold G-protein Coupled Glutamate Receptor Binding Signaling Adaptor Activity Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport	Skeletal Muscle Contraction Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Circadian Rhythm Positive Regulation Of Signal Transduction Response To Nicotine Protein Localization To Synapse Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)	Height ( 18193045) Major depressive disorder ( 20673876)
Protein-Protein Interactions		29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	19 interactors: ABI3 AGAP2 C19orf57 C1orf116 DNM3 EFNB2 FAT1 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 RYR1 RYR2 SHANK1 STX12 TANC1 TRPC1
Entrez ID		3708	9456
HPRD ID		00925	09211
Ensembl ID		ENSG00000150995
Uniprot IDs		B4DER3 B4DGH1 Q14643 Q59H91	Q5U5K4 Q86YM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Glutamate Receptor Signaling Pathway Cell-cell Signaling Cytosolic Calcium Ion Homeostasis G-protein Coupled Glutamate Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Homeostasis Regulation Of Sequestering Of Calcium Ion Behavior Regulation Of Ion Transport Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Transport Regulation Of Ion Homeostasis Cellular Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Synaptic Transmission, Glutamatergic Cellular Cation Homeostasis Calcium Ion Transmembrane Transport Cellular Ion Homeostasis Single-organism Behavior Metal Ion Homeostasis Developmental Process Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Cellular Chemical Homeostasis Learning Or Memory Ion Homeostasis Cognition Synaptic Transmission Regulation Of Synaptic Transmission Calcium Ion Transport Dendritic Spine Organization Cellular Homeostasis Learning Cell Projection Organization Response To Caffeine Multicellular Organismal Development Anatomical Structure Morphogenesis Ion Transmembrane Transport Anatomical Structure Development Chemical Homeostasis Regulation Of Calcium Ion Transport Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Alkaloid Positive Regulation Of Ion Transport Synaptic Transmission, Glutamatergic Long-term Memory Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Determination Of Affect
Tagcloud ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles prognostic proportional shortened signature starvation subgroups vegfa wiley	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei pons syt1
Tagcloud (Intersection) ?		periodicals