ITPR1 and HOMER2

Number of citations of the paper that reports this interaction (PubMedID 9808459)
0

Data Source:
HPRD (in vivo, in vitro)

		ITPR1	HOMER2
Description		inositol 1,4,5-trisphosphate receptor type 1	homer scaffold protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Stereocilium Stereocilium Tip Cell Projection Intracellular Organelle Apical Part Of Cell Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Calcium Channel Inhibitor Activity Protein Domain Specific Binding Phosphatidylinositol Binding Protein Homodimerization Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels	Actin Binding Protein Binding Synaptic Receptor Adaptor Activity G Protein-coupled Glutamate Receptor Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Apoptotic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Single Fertilization Post-embryonic Development Regulation Of Autophagy Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Import Into The Mitochondrion Epithelial Fluid Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Ligand-gated Ion Channel Signaling Pathway	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Negative Regulation Of Interleukin-2 Production Behavioral Response To Cocaine Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32154731 32203549) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)	Bipolar disorder ( 34002096) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Tourette syndrome ( 30818990)
Interacting Genes		32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	14 interacting genes: ABI3 AGAP2 APP DBN1 FXR1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1
Entrez ID		3708	9455
HPRD ID		00925	07269
Ensembl ID		ENSG00000150995	ENSG00000103942
Uniprot IDs		B4DER3 B4DGH1 Q14643 Q59H91	Q9NSB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Intracellular Signal Transduction Signal Transduction G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Transport Regulation Of Cell Communication Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling G Protein-coupled Glutamate Receptor Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle System Process Glutamate Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Protein Phosphorylation Response To Calcium Ion Calcium Ion Transport Phosphorylation Regulation Of Monoatomic Cation Transmembrane Transport Plasma Membrane Negative Regulation Of Signal Transduction Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Multicellular Organismal Process Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Hydrogen Peroxide Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Transport Regulation Of Store-operated Calcium Entry Regulation Of Cell Activation Negative Regulation Of Apoptotic Process Lymphocyte Proliferation Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Calcium Ion Homeostasis Mononuclear Cell Proliferation Protein Kinase Activity	Regulation Of Neuronal Synaptic Plasticity Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Intracellularly Gated Calcium Channel Activity Negative Regulation Of Long-term Synaptic Potentiation Postsynaptic Density Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Protein Tetramerization Neuron Projection Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Dendritic Shaft Monoatomic Ion Homeostasis Glutamate Receptor Signaling Pathway Protein Homooligomerization Growth Cone Lamellipodium Intracellular Monoatomic Cation Homeostasis Postsynapse Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Calcium-mediated Signaling Dendrite Amylin Binding Inorganic Ion Homeostasis Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Regulation Of Postsynapse Organization Cellular Localization Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Cytoplasm Intracellular Monoatomic Ion Homeostasis Ligand-gated Ion Channel Signaling Pathway Dendritic Spine Positive Regulation Of Neurogenesis Regulation Of Dendritic Spine Morphogenesis Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Engulfment Of Target By Autophagosome Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Primary Ureteric Bud Growth Glutamatergic Synapse Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion
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