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ITPR1 and FKBP1A
Number of citations of the paper that reports this interaction (PMID
9346894
)
33
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ITPR1
FKBP1A
Gene Name
inositol 1,4,5-trisphosphate receptor, type 1
FK506 binding protein 1A, 12kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Inner Membrane
Nucleolus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Calcineurin Complex
Postsynaptic Density
Membrane
Integral Component Of Membrane
Sarcoplasmic Reticulum
Platelet Dense Granule Membrane
Platelet Dense Tubular Network
Platelet Dense Tubular Network Membrane
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Terminal Cisterna
Membrane
Z Disc
Sarcoplasmic Reticulum Membrane
Axon Terminus
Extracellular Vesicular Exosome
Molecular Function
Intracellular Ligand-gated Calcium Channel Activity
Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Binding
Calcium Ion Transmembrane Transporter Activity
Calcium Channel Inhibitor Activity
Phosphatidylinositol Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Signal Transducer Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Macrolide Binding
FK506 Binding
Calcium Channel Inhibitor Activity
Enzyme Binding
Hsp70 Protein Binding
Type I Transforming Growth Factor Beta Receptor Binding
Protein Homodimerization Activity
Ion Channel Binding
SMAD Binding
Activin Binding
Biological Process
Response To Hypoxia
Energy Reserve Metabolic Process
Calcium Ion Transport
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Blood Coagulation
Fibroblast Growth Factor Receptor Signaling Pathway
Post-embryonic Development
Platelet Activation
Endoplasmic Reticulum Calcium Ion Homeostasis
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Small Molecule Metabolic Process
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Inositol Phosphate-mediated Signaling
Regulation Of Insulin Secretion
Negative Regulation Of Calcium-mediated Signaling
Voluntary Musculoskeletal Movement
Release Of Sequestered Calcium Ion Into Cytosol
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Calcium Ion Transmembrane Transport
Protein Peptidyl-prolyl Isomerization
Negative Regulation Of Protein Phosphorylation
Heart Morphogenesis
Protein Folding
'de Novo' Protein Folding
Muscle Contraction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Response To Iron Ion
Cytokine-mediated Signaling Pathway
Protein Maturation By Protein Folding
Response To Caffeine
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Binding
Negative Regulation Of Protein Phosphatase Type 2B Activity
Regulation Of Protein Localization
Regulation Of Activin Receptor Signaling Pathway
Protein Refolding
T Cell Proliferation
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Extracellular Fibril Organization
Regulation Of Immune Response
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Heart Trabecula Formation
Chaperone-mediated Protein Folding
Calcium Ion Transmembrane Transport
Regulation Of Amyloid Precursor Protein Catabolic Process
Amyloid Fibril Formation
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Phospholipase C-mediated cascade
Signaling by FGFR in disease
Integration of energy metabolism
cGMP effects
Signaling by Wnt
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
Effects of PIP2 hydrolysis
Platelet calcium homeostasis
DAP12 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Role of phospholipids in phagocytosis
Fcgamma receptor (FCGR) dependent phagocytosis
Signaling by PDGF
DAP12 interactions
Opioid Signalling
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
G alpha (q) signalling events
Signaling by EGFR
GPCR downstream signaling
Platelet homeostasis
Signaling by VEGF
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Platelet activation, signaling and aggregation
Adaptive Immune System
G alpha (q) signalling events
DAG and IP3 signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Downstream signaling of activated FGFR
Nitric oxide stimulates guanylate cyclase
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Innate Immune System
Signalling by NGF
PLC beta mediated events
Regulation of insulin secretion
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
G-protein mediated events
Signaling by Overexpressed Wild-Type EGFR in Cancer
beta-catenin independent WNT signaling
Signaling by FGFR
Ca2+ pathway
Elevation of cytosolic Ca2+ levels
PLC-gamma1 signalling
FCERI mediated Ca+2 mobilization
Loss of Function of TGFBR2 in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Pimecrolimus
Tacrolimus
Sirolimus
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
Gpi-1046
Methyl Methylsulfinylmethyl Sulfide
FKB-001
Heptyl-Beta-D-Glucopyranoside
L-709,587
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
4-Hydroxy-2-Butanone
MYRISTIC ACID
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS
Airflow obstruction (
22837378
)
Breast cancer (
23535729
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
29 interactors:
AHCYL1
AKT1
ARHGAP1
BANK1
BCL2
CA8
CABP1
CCNB1
CDK1
EPB41L1
ERP44
FKBP1A
FYN
GRM1
HOMER1
HOMER2
HOMER3
ITPR3
ITPRIP
LYN
MRVI1
PRKACA
PRKCD
PRKG1
RHOA
RYR2
STARD13
TRPC3
TRPC4
21 interactors:
ACVR1B
ACVRL1
AHSP
APP
BARD1
BMPR1A
DHFR
FKBP4
GLMN
ITPR1
MID1
MTOR
PPP3CA
RYR1
RYR3
SF3B4
TGFB1
TGFB1I1
TGFBR1
TRPC3
YY1
Entrez ID
3708
2280
HPRD ID
00925
01741
Ensembl ID
ENSG00000150995
ENSG00000088832
Uniprot IDs
B4DER3
B4DGH1
Q14643
Q59H91
P62942
Q0VDC6
PDB IDs
1A7X
1B6C
1BKF
1BL4
1D6O
1D7H
1D7I
1D7J
1EYM
1F40
1FAP
1FKB
1FKD
1FKF
1FKG
1FKH
1FKI
1FKJ
1FKR
1FKS
1FKT
1J4H
1J4I
1J4R
1NSG
1QPF
1QPL
2DG3
2DG4
2DG9
2FAP
2FKE
2PPN
2PPO
2PPP
2RSE
3FAP
3H9R
3MDY
4DH0
4FAP
4IPX
Enriched GO Terms of Interacting Partners
?
Regulation Of Calcium Ion Transport
Regulation Of Ion Transport
Response To Wounding
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Protein Localization
Blood Coagulation
Hemostasis
Regulation Of Cellular Localization
Wound Healing
Platelet Activation
Cell Activation
Regulation Of Transmembrane Transporter Activity
Positive Regulation Of Signal Transduction
Regulation Of Body Fluid Levels
Response To Organonitrogen Compound
Regulation Of Intracellular Transport
Signaling
Regulation Of Platelet Aggregation
Cell Communication
Response To Organic Substance
Response To Organic Cyclic Compound
Response To Metal Ion
Cellular Response To Stimulus
Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
G-protein Coupled Glutamate Receptor Signaling Pathway
Positive Regulation Of Transport
Neurotrophin Signaling Pathway
Regulation Of Catalytic Activity
Second-messenger-mediated Signaling
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Intracellular Signal Transduction
Response To Stimulus
Regulation Of Ion Homeostasis
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cation Channel Activity
Regulation Of Calcium Ion Transport Into Cytosol
Regulation Of Platelet Activation
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Activation
Regulation Of Establishment Of Protein Localization
Response To Inorganic Substance
Positive Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Response To Organic Substance
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Transport
Developmental Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Multicellular Organismal Development
Regulation Of Phosphorylation
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Transport
Response To Stress
Regulation Of Intracellular Protein Transport
Regulation Of Cellular Localization
Response To Abiotic Stimulus
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Protein Localization
Positive Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Phosphorylation
Regulation Of SMAD Protein Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Regulation Of Protein Localization To Nucleus
Cell Differentiation
Regulation Of Gene Expression
Anatomical Structure Development
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Cellular Response To Organic Substance
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Intracellular Transport
Response To Stimulus
Negative Regulation Of Cell Differentiation
Activin Receptor Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Cell Differentiation
Signal Transduction By Phosphorylation
Regulation Of Metabolic Process
Regulation Of Epithelial Cell Proliferation
Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Cellular Chemical Homeostasis
Tagcloud
?
autophagy
bcl2
birc5
buffer
constituents
damaged
dataset
degrades
deregulation
distant
eif4ebp1
ero1l
fos
gapdh
gse21653
gse3494
gse7390
inc
lived
organelles
periodicals
prognostic
proportional
shortened
signature
starvation
subgroups
vegfa
wiley
Tagcloud (Difference)
?
autophagy
bcl2
birc5
buffer
constituents
damaged
dataset
degrades
deregulation
distant
eif4ebp1
ero1l
fos
gapdh
gse21653
gse3494
gse7390
inc
lived
organelles
periodicals
prognostic
proportional
shortened
signature
starvation
subgroups
vegfa
wiley
Tagcloud (Intersection)
?