ITPR1 and AHCYL1

Number of citations of the paper that reports this interaction (PubMedID 12525476)
0

Data Source:
HPRD (in vitro, in vivo)

		ITPR1	AHCYL1
Description		inositol 1,4,5-trisphosphate receptor type 1	adenosylhomocysteinase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Calcium Channel Inhibitor Activity Protein Domain Specific Binding Phosphatidylinositol Binding Protein Homodimerization Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels	RNA Binding Adenosylhomocysteinase Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Apoptotic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Single Fertilization Post-embryonic Development Regulation Of Autophagy Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Import Into The Mitochondrion Epithelial Fluid Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Ligand-gated Ion Channel Signaling Pathway	Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Monoatomic Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Monoatomic Anion Transport Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32154731 32203549) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)	Height ( 31562340)
Interacting Genes		32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	25 interacting genes: BID BTG3 CDKN2C CFTR DACH1 GEM HBQ1 HGS HSPA6 ITPR1 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165
Entrez ID		3708	10768
HPRD ID		00925	07613
Ensembl ID		ENSG00000150995	ENSG00000168710
Uniprot IDs		B4DER3 B4DGH1 Q14643 Q59H91	A0A024R0A8 O43865
PDB IDs			3MTG
Enriched GO Terms of Interacting Partners?		Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Intracellular Signal Transduction Signal Transduction G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Transport Regulation Of Cell Communication Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling G Protein-coupled Glutamate Receptor Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle System Process Glutamate Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Protein Phosphorylation Response To Calcium Ion Calcium Ion Transport Phosphorylation Regulation Of Monoatomic Cation Transmembrane Transport Plasma Membrane Negative Regulation Of Signal Transduction Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Multicellular Organismal Process Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Hydrogen Peroxide Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Transport Regulation Of Store-operated Calcium Entry Regulation Of Cell Activation Negative Regulation Of Apoptotic Process Lymphocyte Proliferation Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Calcium Ion Homeostasis Mononuclear Cell Proliferation Protein Kinase Activity
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