RYR1 and RYR2

Number of citations of the paper that reports this interaction (PMID 12213830)
7

Data Source:
HPRD (in vivo)

		RYR1	RYR2
Gene Name		ryanodine receptor 1 (skeletal)	ryanodine receptor 2 (cardiac)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Junctional Membrane Complex T-tubule I Band Sarcoplasmic Reticulum Membrane Extracellular Vesicular Exosome	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding Calcium-release Channel Activity	Intracellular Ligand-gated Calcium Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-release Channel Activity Enzyme Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Protein Self-association Suramin Binding Ion Channel Binding Calcium-induced Calcium Release Activity
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Calcium Ion Transport Cellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling BMP Signaling Pathway Response To Caffeine Ion Transmembrane Transport Calcium-mediated Signaling Using Intracellular Calcium Source Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Type B Pancreatic Cell Apoptotic Process Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Calcium-transporting ATPase Activity
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs		Caffeine Dantrolene Suramin
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Exercise treadmill test traits ( 17903301) Hypertension ( 17554300) Obesity-related traits ( 23251661) Response to cerivastatin ( 21386754) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		12 interactors: CACNA1S CALM1 CAMK2G FKBP1A HOMER1 HOMER2 HOMER3 PRKACA PRKG1 RYR2 S100A1 TRDN	14 interactors: AKAP6 ALB CACNA1C CALM1 FKBP1B HOMER1 ITPR1 MDM2 PRKACA PRKAR2A RYR1 RYR3 SMAD5 SRI
Entrez ID		6261	6262
HPRD ID		01618	01619
Ensembl ID		ENSG00000196218	ENSG00000198626
Uniprot IDs		P21817	Q92736
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Muscle System Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Contraction Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Second-messenger-mediated Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Ion Homeostasis Positive Regulation Of Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Organic Cyclic Compound Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Transport Response To Alkaloid Regulation Of Muscle Contraction Regulation Of Sequestering Of Calcium Ion Regulation Of Heart Contraction Response To Organonitrogen Compound Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Muscle Structure Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Myotube Differentiation Response To Stimulus Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transport Homeostatic Process Muscle Contraction Regulation Of Ion Transmembrane Transport Muscle System Process Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Organic Substance Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Transport Cytosolic Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cellular Localization Regulation Of Insulin Secretion Regulation Of Establishment Of Protein Localization Regulation Of Striated Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Peptide Hormone Secretion Regulation Of Intracellular Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Localization Regulation Of Hormone Secretion Response To Organonitrogen Compound Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Homeostasis Energy Reserve Metabolic Process Ion Homeostasis Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Cellular Response To Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt	12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine ryr1 scorton serca2 thrive vastly
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt	12kda atlantic bedford biphenyls congener congeners creek dioxin exceed f2 fk506 fkbp12 fundulus generations heritable heteroclitus hydrocarbon killifish nbh ndl pcb pcbs ryanodine scorton serca2 thrive vastly
Tagcloud (Intersection) ?		ryr1