RYR1 and CAV3

Number of citations of the paper that reports this interaction (PubMedID 23071107)
64

Data Source:
BioGRID (pull down)

		RYR1	CAV3
Description		ryanodine receptor 1	caveolin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc T-tubule Neuromuscular Junction Vesicle Protein-containing Complex Sarcolemma Membrane Raft
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding ATP Binding Intracellularly Gated Calcium Channel Activity Metal Ion Binding Calcium-induced Calcium Release Activity	Calcium Channel Regulator Activity Protein Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Enzyme Binding Alpha-tubulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Muscle Contraction Striated Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Caffeine	MAPK Cascade Response To Hypoxia Plasma Membrane Repair Regulation Of Heart Rate Response To Ischemia Cardiac Muscle Hypertrophy Triglyceride Metabolic Process Calcium Ion Transport Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Myotube Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Cytosolic Calcium Ion Concentration Nucleus Localization Establishment Of Localization In Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ionomycin Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Stimuli-sensing channels Ion homeostasis	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		Caffeine Dantrolene Suramin Tetracaine
Diseases		Central core disease	Limb-girdle muscular dystrophy (LGMD) Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)	Caudate activity during reward ( 28927378) Takayasu arteritis ( 33308445)
Interacting Genes		19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3	21 interacting genes: ADRB2 DAG1 DYSF EGFR GNAS INSR JPH2 KCNJ12 NOS1 PBX3 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RBFA RYR1 SENP1 SLC22A11 SLC8A1 SNCA
Entrez ID		6261	859
HPRD ID		01618	03154
Ensembl ID		ENSG00000196218	ENSG00000182533
Uniprot IDs		A0A8I5KSR1 M0R014 P21817	P56539
PDB IDs		6UHI 6UHS
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Regulation Of Metal Ion Transport Regulation Of Muscle System Process Regulation Of Monoatomic Ion Transport Z Disc Transmembrane Transporter Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of System Process Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Sequestering Of Calcium Ion Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Transport Regulation Of Striated Muscle Contraction G Protein-coupled Glutamate Receptor Binding Regulation Of Heart Contraction Muscle System Process Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Complex Calcium-mediated Signaling Regulation Of Calcium-mediated Signaling Sarcoplasmic Reticulum Membrane Signal Transduction Regulation Of Multicellular Organismal Process Junctional Sarcoplasmic Reticulum Membrane Calcium Channel Regulator Activity Regulation Of Store-operated Calcium Entry G Protein-coupled Glutamate Receptor Signaling Pathway System Process Striated Muscle Cell Development Intracellular Signaling Cassette Striated Muscle Contraction Muscle Contraction Cardiac Muscle Hypertrophy M Band Protein Kinase A Regulatory Subunit Binding I Band Response To Muscle Stretch Negative Regulation Of Interleukin-2 Production Muscle Hypertrophy Muscle Cell Development Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Intracellular Signal Transduction	Regulation Of System Process Sarcolemma T-tubule Muscle System Process Regulation Of Monoatomic Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Transport Regulation Of Muscle Contraction Muscle Contraction Receptor Complex Regulation Of Metal Ion Transport System Process Negative Regulation Of Serotonin Uptake Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Regulation Of Calcium Ion Transport Regulation Of Serotonin Uptake Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Endothelial Growth Factor Binding Homeostatic Process Regulation Of Muscle System Process Sarcoplasmic Reticulum Membrane Positive Regulation Of The Force Of Heart Contraction Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Regulation Of Sequestering Of Calcium Ion Plasma Membrane Z Disc Glomerular Capillary Formation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Response To Growth Factor Positive Regulation Of Transport Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chemical Homeostasis Calcium-mediated Signaling Cellular Response To Oxygen-containing Compound Junctional Sarcoplasmic Reticulum Membrane Cellular Response To Caffeine Apical Plasma Membrane Positive Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Sarcoplasmic Reticulum Platelet-derived Growth Factor Binding Regulation Of Heart Contraction
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