RYR1 and HOMER3

Number of citations of the paper that reports this interaction (PMID 12223488)
19

Data Source:
HPRD (in vivo, in vitro)

		RYR1	HOMER3
Gene Name		ryanodine receptor 1 (skeletal)	homer homolog 3 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Junctional Membrane Complex T-tubule I Band Sarcoplasmic Reticulum Membrane Extracellular Vesicular Exosome	Cellular_component Cytoplasm Cytosol Plasma Membrane Cell Junction Basal Part Of Cell Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Protease Binding Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding Calcium-release Channel Activity	Protein Binding Protein C-terminus Binding Protein Domain Specific Binding G-protein Coupled Glutamate Receptor Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Protein Targeting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry
Pathways		Ion channel transport Stimuli-sensing channels
Drugs		Caffeine Dantrolene Suramin
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CACNA1S CALM1 CAMK2G FKBP1A HOMER1 HOMER2 HOMER3 PRKACA PRKG1 RYR2 S100A1 TRDN	28 interactors: ABI2 ABI3 APP CEBPB DYNLL2 EAF1 EIF3D FAT1 FRYL GRM5 HOMER1 ITPR1 MOS NEBL PAX6 PKN1 POM121 PPP1R18 PSMA1 PSMA2 PSMC5 RUNX1T1 RYR1 SNRPF SRPK2 TRPC1 USP2 WIPF1
Entrez ID		6261	9454
HPRD ID		01618	07270
Ensembl ID		ENSG00000196218	ENSG00000051128
Uniprot IDs		P21817	B2RA10 Q9NSC5
PDB IDs			2P8V 3CVF
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Muscle System Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Contraction Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Second-messenger-mediated Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Ion Homeostasis Positive Regulation Of Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Organic Cyclic Compound Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Transport Response To Alkaloid Regulation Of Muscle Contraction Regulation Of Sequestering Of Calcium Ion Regulation Of Heart Contraction Response To Organonitrogen Compound Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Muscle Structure Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Myotube Differentiation Response To Stimulus Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance	Positive Regulation Of Cell Cycle Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Gene Expression Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Glutamate Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Positive Regulation Of Ligase Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Intracellular Signal Transduction Response To Stimulus Signal Transduction Single-organism Behavior Cell Differentiation Regulation Of Ubiquitin-protein Transferase Activity Movement Of Cell Or Subcellular Component Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Arrest
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt	abetapp alzheimer analyzing assembly coil coiled deposition derivative emphasis evh1 generation herein importantly interacting interaction interacts manipulate metabolism offer plaques players polymerization possibly seems senile serine tail
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt	abetapp alzheimer analyzing assembly coil coiled deposition derivative emphasis evh1 generation herein importantly interacting interaction interacts manipulate metabolism offer plaques players polymerization possibly seems senile serine tail
Tagcloud (Intersection) ?