RYR1 and PDLIM3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		RYR1	PDLIM3
Description		ryanodine receptor 1	PDZ and LIM domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex	Stress Fiber Cytoplasm Cytosol Adherens Junction Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding ATP Binding Intracellularly Gated Calcium Channel Activity Metal Ion Binding Calcium-induced Calcium Release Activity	Actin Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Muscle Contraction Striated Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Caffeine	Actin Filament Organization Heart Development Actin Cytoskeleton Organization Muscle Structure Development
Pathways		Stimuli-sensing channels Ion homeostasis
Drugs		Caffeine Dantrolene Suramin Tetracaine
Diseases		Central core disease
GWAS		Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)
Interacting Genes		19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3	11 interacting genes: ABCA1 ACTN2 FHL1 MYOT MYOZ2 MYOZ3 MYPN PALLD RANBP2 RHOU RYR1
Entrez ID		6261	27295
HPRD ID		01618	08388
Ensembl ID		ENSG00000196218	ENSG00000154553
Uniprot IDs		A0A8I5KSR1 M0R014 P21817	A0A087WYF8 A0A2U3TZH4 Q53GG5
PDB IDs		6UHI 6UHS
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Regulation Of Metal Ion Transport Regulation Of Muscle System Process Regulation Of Monoatomic Ion Transport Z Disc Transmembrane Transporter Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of System Process Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Sequestering Of Calcium Ion Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Transport Regulation Of Striated Muscle Contraction G Protein-coupled Glutamate Receptor Binding Regulation Of Heart Contraction Muscle System Process Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Complex Calcium-mediated Signaling Regulation Of Calcium-mediated Signaling Sarcoplasmic Reticulum Membrane Signal Transduction Regulation Of Multicellular Organismal Process Junctional Sarcoplasmic Reticulum Membrane Calcium Channel Regulator Activity Regulation Of Store-operated Calcium Entry G Protein-coupled Glutamate Receptor Signaling Pathway System Process Striated Muscle Cell Development Intracellular Signaling Cassette Striated Muscle Contraction Muscle Contraction Cardiac Muscle Hypertrophy M Band Protein Kinase A Regulatory Subunit Binding I Band Response To Muscle Stretch Negative Regulation Of Interleukin-2 Production Muscle Hypertrophy Muscle Cell Development Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Intracellular Signal Transduction	Z Disc FATZ Binding Actin Binding Actin Cytoskeleton Actin Cytoskeleton Organization Sarcomere Organization Actin Filament-based Process Sarcomere Channel Activator Activity Telethonin Binding Muscle Alpha-actinin Binding Actomyosin Structure Organization Dendrite Self-avoidance Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules I Band Focal Adhesion Positive Regulation Of Potassium Ion Transport Cell-cell Adhesion Mediator Activity Sarcoplasmic Reticulum Membrane Structural Constituent Of Muscle Cytoskeleton Organization Axon Guidance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Neuron Projection Guidance Podosome Neuron Recognition Organelle Organization Sphingolipid Floppase Activity Actin Filament Uncapping Regulation Of Intracellular Transport Cytoskeletal Protein Binding Sarcoplasmic Reticulum Striated Muscle Cell Development Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Titin Z Domain Binding Cytoplasmic Periphery Of The Nuclear Pore Complex Ryanodine Receptor Complex Regulation Of Potassium Ion Transport Actin Filament Regulation Of High-density Lipoprotein Particle Assembly Muscle Cell Development Phospholipase C-activating Angiotensin-activated Signaling Pathway Ryanodine-sensitive Calcium-release Channel Activity Skeletal Muscle Fiber Adaptation Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Axon Phosphatidylserine Floppase Activity
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