RYR1

Name	ryanodine receptor 1
Structure
Interactors	19 interactors: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding ATP Binding Intracellularly Gated Calcium Channel Activity Metal Ion Binding Calcium-induced Calcium Release Activity
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Muscle Contraction Striated Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Caffeine
Pathways	Stimuli-sensing channels Ion homeostasis
Drugs	Caffeine Dantrolene Suramin Tetracaine
Diseases	Central core disease
GWAS	Abstraction and mental flexibility ( 31596458 ) Appendicular lean mass ( 33097823 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Diisocyanate-induced asthma ( 25918132 ) Peanut allergy (parent-of-origin effect) ( 29489655 ) White blood cell count (basophil) ( 27863252 )
Entrez ID	6261
HPRD ID	01618
Ensembl ID	ENSG00000196218
Uniprot IDs	A0A8I5KSR1 M0R014 P21817
PDB IDs	6UHI 6UHS
GO Terms Enriched among Interactors ?	Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Regulation Of Metal Ion Transport Regulation Of Muscle System Process Regulation Of Monoatomic Ion Transport Z Disc Transmembrane Transporter Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of System Process Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Sequestering Of Calcium Ion Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Transport Regulation Of Striated Muscle Contraction G Protein-coupled Glutamate Receptor Binding Regulation Of Heart Contraction Muscle System Process Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Complex Calcium-mediated Signaling Regulation Of Calcium-mediated Signaling Sarcoplasmic Reticulum Membrane Signal Transduction Regulation Of Multicellular Organismal Process Junctional Sarcoplasmic Reticulum Membrane Calcium Channel Regulator Activity Regulation Of Store-operated Calcium Entry G Protein-coupled Glutamate Receptor Signaling Pathway System Process Striated Muscle Cell Development Intracellular Signaling Cassette Striated Muscle Contraction Muscle Contraction Cardiac Muscle Hypertrophy M Band Protein Kinase A Regulatory Subunit Binding I Band Response To Muscle Stretch Negative Regulation Of Interleukin-2 Production Muscle Hypertrophy Muscle Cell Development Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Intracellular Signal Transduction