ROS1 and PTPN6

Number of citations of the paper that reports this interaction (PMID 11266449)
9

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		ROS1	PTPN6
Gene Name		ROS proto-oncogene 1 , receptor tyrosine kinase	protein tyrosine phosphatase, non-receptor type 6
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Nucleus Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Alpha-beta T Cell Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding
	Biological Process	Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Growth Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of TOR Signaling Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation Apoptotic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Costimulation by the CD28 family Signaling by SCF-KIT Interferon gamma signaling Regulation of KIT signaling Interleukin receptor SHC signaling Interferon alpha/beta signaling Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Platelet homeostasis Platelet sensitization by LDL Interleukin receptor SHC signaling PD-1 signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System
Drugs
Diseases
GWAS		Lung cancer ( 23143601) QT interval (interaction) ( 23459443)
Protein-Protein Interactions		6 interactors: ABL1 IKBKG LPHN1 PTPN11 PTPN6 VAV3	98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		6098	5777
HPRD ID		01295	01475
Ensembl ID		ENSG00000047936	ENSG00000111679
Uniprot IDs		P08922	P29350 Q53XS4
PDB IDs		3ZBF	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Abortive Mitotic Cell Cycle B Cell Receptor Signaling Pathway Regulation Of Kinase Activity Fc Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Defense Response Regulation Of Body Fluid Levels Megakaryocyte Development Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Regulation Of MAPK Cascade Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Formation Response To Wounding Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Negative Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Cell Migration Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility B Cell Homeostasis Regulation Of MAP Kinase Activity	Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune System Process Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Immune Response Cellular Response To Stimulus Regulation Of Cell Activation Cell Activation Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Immune Response-regulating Signaling Pathway Defense Response Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Lymphocyte Activation Innate Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Cell Migration Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Blood Coagulation Hemostasis Cell Motility Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Intracellular Signal Transduction Leukocyte Activation Leukocyte Differentiation Leukocyte Migration Fc Receptor Signaling Pathway Regulation Of Signaling Response To Cytokine Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e	a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike
Tagcloud (Difference) ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e	a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike
Tagcloud (Intersection) ?