ROS1 and VAV3

Number of citations of the paper that reports this interaction (PMID 11094073)
32

Data Source:
HPRD (two hybrid, in vivo)

		ROS1	VAV3
Gene Name		ROS proto-oncogene 1 , receptor tyrosine kinase	vav 3 guanine nucleotide exchange factor
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Growth Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of TOR Signaling Regulation Of ERK1 And ERK2 Cascade	Angiogenesis Vesicle Fusion Cellular Response To DNA Damage Stimulus Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Signal Transduction Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Axon guidance FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Lung cancer ( 23143601) QT interval (interaction) ( 23459443)	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Hypothyroidism ( 22493691)
Protein-Protein Interactions		6 interactors: ABL1 IKBKG LPHN1 PTPN11 PTPN6 VAV3	17 interactors: EGFR ERBB2 ERBB3 ESR1 GRB2 IGF1R INSR LCP2 PIK3R1 PLCG1 RAC1 RHOA RHOG ROS1 SH3BP2 SHC1 ZYX
Entrez ID		6098	10451
HPRD ID		01295	05706
Ensembl ID		ENSG00000047936	ENSG00000134215
Uniprot IDs		P08922	Q9UKW4
PDB IDs		3ZBF	2D86
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Abortive Mitotic Cell Cycle B Cell Receptor Signaling Pathway Regulation Of Kinase Activity Fc Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Defense Response Regulation Of Body Fluid Levels Megakaryocyte Development Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Regulation Of MAPK Cascade Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Formation Response To Wounding Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Negative Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Cell Migration Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility B Cell Homeostasis Regulation Of MAP Kinase Activity	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Wound Healing Regulation Of Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Wounding Signal Transduction Cellular Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Platelet Activation Response To Fibroblast Growth Factor Regulation Of Phosphorylation Blood Coagulation Intracellular Signal Transduction Hemostasis Response To Organic Substance Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Axonogenesis Phosphatidylinositol 3-kinase Signaling Axon Development Regulation Of Immune Response Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Immune Response Regulation Of MAPK Cascade Axon Guidance Neuron Projection Morphogenesis
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vinorelbine
Tagcloud (Difference) ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e	anticancer atlas ccle computational consequences cosmic encyclopedia harboring identifying illustrated investigating mapped midostaurin ncf1 nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vinorelbine
Tagcloud (Intersection) ?		driver