ROS1

Gene Name		ROS proto-oncogene 1 , receptor tyrosine kinase
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding
	Biological Process	Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Growth Peptidyl-tyrosine Phosphorylation Cell Differentiation Regulation Of TOR Signaling Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases
GWAS		Lung cancer ( 23143601) QT interval (interaction) ( 23459443)
Protein-protein Interactions		6 interactors: ABL1 IKBKG LPHN1 PTPN11 PTPN6 VAV3
Entrez ID		6098
HPRD ID		01295
Ensembl ID		ENSG00000047936
Uniprot IDs		P08922
PDB IDs		3ZBF
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Abortive Mitotic Cell Cycle B Cell Receptor Signaling Pathway Regulation Of Kinase Activity Fc Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Defense Response Regulation Of Body Fluid Levels Megakaryocyte Development Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Wound Healing Regulation Of MAPK Cascade Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Formation Response To Wounding Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Negative Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Cell Migration Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility B Cell Homeostasis Regulation Of MAP Kinase Activity
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret socs5 targetable uniform v600e