ROS1 and ADGRL1

Number of citations of the paper that reports this interaction (PubMedID 10958799)
0

Data Source:
HPRD (two hybrid)

		ROS1	ADGRL1
Description		ROS proto-oncogene 1, receptor tyrosine kinase	adhesion G protein-coupled receptor L1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Plasma Membrane Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Neuron Projection Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding
	Biological Process	Regulation Of Cell Growth Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Cell Differentiation Regulation Of TOR Signaling Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway
Pathways
Drugs		Crizotinib Entrectinib Fostamatinib
Diseases		Non-small cell lung cancer
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Lung adenocarcinoma ( 28604730) Lung cancer ( 23143601) Night sleep phenotypes ( 27126917) Pneumococcal meningitis ( 31092817) QT interval (drug interaction) ( 23459443)	L1-L4 bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		7 interacting genes: ABL1 ADGRL1 FGFR4 IKBKG PTPN11 PTPN6 VAV3	10 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2 SHANK3
Entrez ID		6098	22859
HPRD ID		01295	14305
Ensembl ID		ENSG00000047936	ENSG00000072071
Uniprot IDs		P08922 Q5H8Y1	O94910
PDB IDs		3ZBF 4UXL 7Z5W 7Z5X
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Positive Regulation Of Cell Activation Integrin-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling T Cell Receptor Signaling Pathway Bergmann Glial Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Immune Effector Process Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Cell Adhesion Molecule Binding Neutrophil Activation Involved In Immune Response Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of Lymphocyte Activation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Platelet Formation Megakaryocyte Development Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Homeostasis Of Number Of Cells Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Cell Activation B Cell Homeostasis Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Activation Regulation Of MAPK Cascade Astrocyte Differentiation	Ionotropic Glutamate Receptor Binding Vocalization Behavior Synaptic Receptor Adaptor Activity Neuron Projection Social Behavior Dendritic Spine Morphogenesis Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Dendritic Spine Learning Neuron Projection Organization Postsynapse Organization Receptor Clustering Neuromuscular Process Controlling Balance AMPA Glutamate Receptor Clustering Modulation Of Excitatory Postsynaptic Potential Modulation Of Chemical Synaptic Transmission Protein Localization To Synapse Postsynaptic Membrane Scaffold Protein Binding Neuron Spine Postsynaptic Density Learning Or Memory Protein Localization To Cell Junction Associative Learning Cognition Cell Projection Neurotransmitter-gated Ion Channel Clustering Neuromuscular Process SH3 Domain Binding Regulation Of Nervous System Process Postsynaptic Density Organization Positive Regulation Of Synaptic Transmission Adult Behavior Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Synapse Postsynaptic Specialization Organization Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Adherens Junction Regulation Of Synaptic Plasticity Developmental Maturation Negative Regulation Of Actin Filament Bundle Assembly Nervous System Development Positive Regulation Of Dendritic Spine Development Ligand-gated Ion Channel Signaling Pathway
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