ROCK1 and VIM

Number of citations of the paper that reports this interaction (PubMedID 9565595)
0

Data Source:
HPRD (in vitro, in vivo)

		ROCK1	VIM
Description		Rho associated coiled-coil containing protein kinase 1	vimentin
Image
GO Annotations	Cellular Component	Golgi Membrane Ruffle Extracellular Region Cytoplasm Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Lamellipodium Bleb Secretory Granule Lumen Cell Projection Schaffer Collateral - CA1 Synapse	Nucleus Cytoplasm Peroxisome Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Membrane Nuclear Matrix Axon Cell Leading Edge Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity	RNA Binding Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein Domain Specific Binding Identical Protein Binding Molecular Adaptor Activity Scaffold Protein Binding Keratin Filament Binding
	Biological Process	Mitotic Cytokinesis Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Apical Constriction Apoptotic Process Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Neuron Projection Development Bleb Assembly Negative Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Keratinocyte Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Phosphate Metabolic Process Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Negative Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Regulation Of Microtubule Cytoskeleton Organization Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Regulation Of Synapse Maturation Podocyte Cell Migration Motor Neuron Apoptotic Process Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Neuron Projection Arborization Positive Regulation Of Amyloid-beta Clearance Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cell Junction Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility Negative Regulation Of Motor Neuron Apoptotic Process	Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Astrocyte Development Neuron Projection Development Positive Regulation Of Collagen Biosynthetic Process Regulation Of MRNA Stability Intermediate Filament-based Process Intermediate Filament Organization Bergmann Glial Cell Differentiation Lens Fiber Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Cellular Response To Type II Interferon
Pathways		Apoptotic cleavage of cellular proteins EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOH GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RND3 GTPase cycle	Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling RHOBTB1 GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Hydroxyfasudil (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE Fasudil Y-27632 Ripasudil Netarsudil Belumosudil	Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Lysophosphatidylcholine levels ( 31551469) Telomere length ( 30185882)	Aspartate aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)
Interacting Genes		40 interacting genes: ADD1 ARHGAP24 CASP3 CASP7 CDC25A CDC34 CFAP206 CRMP1 DES DPYSL2 EZR FAM124A GFAP HMGB2 IKBKB IRS1 ITSN2 LIMK1 LIMK2 LINC00452 LMO2 MAGEB4 MLC1 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOB RHOC RND3 SMAD2 SMAD5 TPPP TRIM15 TSG101 UBE2T VIM	188 interacting genes: ABLIM1 AKT1 ANKRD35 ANXA7 APIP APLP1 APP ARMC7 ARMCX2 ATN1 BAG4 BFSP1 BHLHE40 BRD1 BYSL CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CATSPERT CBX8 CCDC187 CDH5 CDK1 CDKN1A CEP126 CHD3 COPS6 CRCT1 CREB1 CRMP1 CT55 CWF19L2 DCTN1 DEFB1 DIS3L2 DNM1L DPPA4 DSCAM DSP DUX4 DYNLL1 ENTR1 EPB41L2 ESS2 EXOSC7 FABP4 FAM107A FAM118B FAM161A FUBP1 FXR1 FXR2 GADD45A GEM GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HSPB1 HTRA2 ING5 IP6K1 ITGB4 IVNS1ABP KARS1 KAT7 KIAA0408 KIF15 KIF9 KIFC3 KRT20 LGALS14 LINC01554 LORICRIN LRIF1 MAFG MAN2A2 MCPH1 MEN1 MICAL1 MRPL44 MTDH NEFL NEIL3 NFATC2 NFKBID NIF3L1 NME2 NOC4L NR1H2 NUP85 NXF1 OGT OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PKP2 PLA2G2A PLA2G4A PLEC PLK1 PNMA5 POLR1C PPHLN1 PPL PPP1R18 PRKACA PRPF6 PRPH PSMA1 PSMC5 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM11 RBM22 RBM48 RIBC2 ROCK1 RPA1 SCNM1 SERBP1 SETDB1 SFPQ SH3GL3 SH3YL1 SHANK3 SIRPA SIRT6 SLC25A6 SLC27A6 SMAD3 SMARCB1 SNW1 SRRT STX1A SUMO2 SUMO3 SYN1 TAB2 TCEA2 TCHP TLE5 TNFRSF14 TNNT1 TRIM14 TRIM15 TRIM28 TRIM29 TRIOBP TSC1 TSC22D1 TTR TUBA1C TUBGCP4 TXLNB TXN TXN2 UBC UPP1 UPP2 UROD USP7 UTP14A WBP11 WDR59 WHR1 XRCC4 YAE1 YWHAE YWHAZ ZHX1 ZNF384 ZNF572
Entrez ID		6093	7431
HPRD ID		03414	01899
Ensembl ID		ENSG00000067900	ENSG00000026025
Uniprot IDs		Q13464	P08670 V9HWE1
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S 4L2W 4W7P 4YVC 4YVE 5BML 5F5P 5HVU 5KKS 5KKT 5UZJ 5WNE 5WNF 5WNG 5WNH 6E9W 7JOU 7S25 7S26 8P0S 8ZH5	1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1 4MCY 4MCZ 4MD0 4MD5 4MDI 4MDJ 4YPC 4YV3 5WHF 6ATF 6ATI 6BIR 6YXK 8RVE 8TRQ 8TRR
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cytoskeleton Supramolecular Fiber Organization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cytoplasm Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Astral Microtubule Organization Regulation Of Actin Filament-based Process Actin Filament Organization Positive Regulation Of Protein Localization To Endosome Negative Regulation Of Cell Projection Organization Regulation Of Protein-containing Complex Assembly Skeletal Muscle Satellite Cell Migration Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Establishment Of Epithelial Cell Apical/basal Polarity Protein Kinase Binding Regulation Of Establishment Of Endothelial Barrier Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Cytoplasmic Microtubule Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Filament Bundle Organization Actin Cytoskeleton Organization Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Intracellular Signaling Cassette Polarized Epithelial Cell Differentiation Cytoskeletal Protein Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cellular Component Size Regulation Of Organelle Assembly Negative Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Cellular Developmental Process Cellular Response To Staurosporine Cell Differentiation Actin Filament-based Process Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Polarity Regulation Of Adherens Junction Organization	Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Regulation Of Protein Localization To Nucleus Protein Binding Regulation Of Protein Localization Negative Regulation Of Metabolic Process Structural Constituent Of Cytoskeleton Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Intermediate Filament Organization RNA Binding Regulation Of RNA Metabolic Process Execution Phase Of Apoptosis Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Organelle Organization Nucleic Acid Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Programmed Cell Death Cytoskeleton Organization Cell Death Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Cytosol Intermediate Filament Apoptotic Process Positive Regulation Of Protein Localization Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Cornified Envelope Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?