ROCK1 and ARHGAP24

Number of citations of the paper that reports this interaction (PMID 16862148)
88

Data Source:
HPRD (in vivo)

		ROCK1	ARHGAP24
Gene Name		Rho-associated, coiled-coil containing protein kinase 1	Rho GTPase activating protein 24
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb	Cytosol Cytoskeleton Focal Adhesion Cell Projection
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding	Protein Binding Rac GTPase Activator Activity
	Biological Process	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Angiogenesis Small GTPase Mediated Signal Transduction Cell Differentiation Activation Of Rac GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Ruffle Assembly
Pathways		Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Rho GTPase cycle Signaling by Rho GTPases
Drugs		HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS			Electrocardiographic traits ( 20062063) Obesity-related traits ( 23251661) PR interval ( 20062060 23139255)
Protein-Protein Interactions		32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM	3 interactors: APP FLNA ROCK1
Entrez ID		6093	83478
HPRD ID		03414	09804
Ensembl ID			ENSG00000138639
Uniprot IDs		Q13464	Q8N264
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly	Platelet Degranulation Cell Morphogenesis Involved In Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cell Projection Organization Cell Adhesion Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cell Projection Assembly Cell Development Cellular Component Assembly Collateral Sprouting Axon Midline Choice Point Recognition Membrane To Membrane Docking Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Apical Constriction Axon Choice Point Recognition Axon Guidance Blood Coagulation Hemostasis Posttranscriptional Regulation Of Gene Expression Anatomical Structure Morphogenesis Neuron Remodeling Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Bleb Assembly Secretion By Cell MRNA Transcription From RNA Polymerase II Promoter Single Organismal Cell-cell Adhesion Axonogenesis Myoblast Migration Leukocyte Tethering Or Rolling Axon Development MRNA Transcription Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Secretion Neuron Projection Morphogenesis Actin Filament-based Process Cellular Copper Ion Homeostasis Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface Cell Activation Mitotic Spindle Assembly Early Endosome To Late Endosome Transport
Tagcloud ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	acted antagonizing catalytic contributes drives encodes gtpase independently invasion luminal mesenchymal metastasis microrna module oncogenic opposed overexpressed poorly promoted promotes rac1 ras rasal2 relapse subset tnbc triple tumorigenesis
Tagcloud (Difference) ?		angiogenic au contributor decay disperse dispersion ecs eliciting herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	acted antagonizing catalytic contributes drives encodes independently invasion luminal mesenchymal metastasis microrna module oncogenic opposed overexpressed poorly promoted promotes rac1 ras rasal2 relapse subset tnbc triple tumorigenesis
Tagcloud (Intersection) ?		gtpase