ROCK1 and EZR

Number of citations of the paper that reports this interaction (PMID 11387207)
63

Data Source:
HPRD (in vivo)

		ROCK1	EZR
Gene Name		Rho-associated, coiled-coil containing protein kinase 1	ezrin
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways		Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs		HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		6093	7430
HPRD ID		03414	00475
Ensembl ID			ENSG00000092820
Uniprot IDs		Q13464	P15311
PDB IDs		1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S	1NI2
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?