DOK4 and RET

Number of citations of the paper that reports this interaction (PMID 11470823)
30

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DOK4	RET
Gene Name		docking protein 4	ret proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft
	Molecular Function	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs			Imatinib
Diseases
GWAS			Hirschsprung's disease ( 19196962)
Protein-Protein Interactions		11 interactors: CRK EGFR ERBB2 FYN IGF1R INSR OPRM1 RASA1 RET SRC TEK	36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3
Entrez ID		55715	5979
HPRD ID		16316	01266
Ensembl ID		ENSG00000125170	ENSG00000165731
Uniprot IDs		H3BQ19 Q8TEW6	P07949 Q9BTX6
PDB IDs			1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Catalytic Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Kinase B Signaling Response To Growth Factor Response To Organic Substance Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Organic Substance Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Kinase Activity Regulation Of ERK1 And ERK2 Cascade Response To Peptide Hormone Immune System Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Response To Hormone Neuron Development Generation Of Neurons Axonogenesis Anatomical Structure Morphogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Difference) ?		17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Intersection) ?