DOK4 and OPRM1

Number of citations of the paper that reports this interaction (PMID 23840749)
1

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		DOK4	OPRM1
Gene Name		docking protein 4	opioid receptor, mu 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft
	Molecular Function	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development	Acute Inflammatory Response To Antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Locomotory Behavior Negative Regulation Of Cell Proliferation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide Cellular Response To Stress Wound Healing Response To Cocaine Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G-protein activation Class A/1 (Rhodopsin-like receptors) Opioid Signalling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Tramadol Morphine Codeine Hydromorphone Methadone Oxycodone Levallorphan Butorphanol Propoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Levomethadyl Acetate Methadyl Acetate 3-Methylthiofentanyl Dimethylthiambutene Heroin Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan Methylnaltrexone
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		11 interactors: CRK EGFR ERBB2 FYN IGF1R INSR OPRM1 RASA1 RET SRC TEK	23 interactors: ADRBK2 CALM1 COPS5 DNAJB4 DOK4 DOK5 FLNA GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 KCNF1 OPRD1 PLD2 PPL RANBP9 SIAH1 SIAH2 UBC VAPA WLS ZYX
Entrez ID		55715	4988
HPRD ID		16316	02484
Ensembl ID		ENSG00000125170	ENSG00000112038
Uniprot IDs		H3BQ19 Q8TEW6	P35372
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Peptidyl-amino Acid Modification Regulation Of Catalytic Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Kinase B Signaling Response To Growth Factor Response To Organic Substance Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Organic Substance Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Kinase Activity Regulation Of ERK1 And ERK2 Cascade Response To Peptide Hormone Immune System Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Response To Hormone Neuron Development Generation Of Neurons Axonogenesis Anatomical Structure Morphogenesis	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Platelet Activation Signal Transduction Regulation Of Signal Transduction Response To Stimulus Dopamine Receptor Signaling Pathway Regulation Of Signaling Synaptic Transmission Cell-cell Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Calcium Ion Transport Cellular Response To Stimulus Blood Coagulation Hemostasis Establishment Of Localization In Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Receptor Metabolic Process G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cellular Localization Regulation Of Cellular Process Regulation Of Ion Transport Vesicle-mediated Transport Cell Activation Cytoplasmic Transport Response To Wounding Cell Projection Organization Negative Regulation Of Signaling Response To Stress Negative Regulation Of Calcium Ion Transport Receptor Internalization Transport Nervous System Development Neuron Projection Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Membrane Organization Cellular Process Activation Of Phospholipase C Activity
Tagcloud ?		17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?		17p12 19q13 4q27 5p13 7q36 9q34 amacr bcl3 ccl17 ccl22 cd30 cdk9 chemoresponsive cnas cx3cl1 encompassed id4 il10 il21 lcn2 nell1 nonrandom ppargc1a ptges recurring reed spry1 sternberg txnip	13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?