DOK4 and LIX1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DOK4	LIX1
Description		docking protein 4	limb and CNS expressed 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of MAPK Cascade	Autophagosome Maturation
Pathways		RET signaling
Drugs
Diseases
GWAS
Interacting Genes		21 interacting genes: CRK EGFR ERBB2 FYN IGF1R INCA1 INSR LIX1 MAPRE3 OLIG1 OPRM1 PAX8 PFDN5 PTK2 RASA1 RBP7 RET RHOU SRC STAT2 TEK	5 interacting genes: APPL2 DOK4 EMSY FAM110A TSACC
Entrez ID		55715	167410
HPRD ID		16316	08069
Ensembl ID		ENSG00000125170	ENSG00000145721
Uniprot IDs		H3BQ19 Q8TEW6	Q8N485
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Ephrin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Developmental Process Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Positive Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Receptor Complex Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Dendritic Spine Maintenance Positive Regulation Of Locomotion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Shape Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Binding Signal Transduction Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Adhesion ERBB2 Signaling Pathway Protein Phosphorylation	Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Phagosome Membrane Cold Acclimation
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