DOK4 and STAT2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DOK4	STAT2
Description		docking protein 4	signal transducer and activator of transcription 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane ISGF3 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of MAPK Cascade	Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mitochondrial Fission
Pathways		RET signaling	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs
Diseases
GWAS			Axial length ( 24144296) Height ( 20881960 23456168 25429064) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 19169254 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: CRK EGFR ERBB2 FYN IGF1R INCA1 INSR LIX1 MAPRE3 OLIG1 OPRM1 PAX8 PFDN5 PTK2 RASA1 RBP7 RET RHOU SRC STAT2 TEK	22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		55715	6773
HPRD ID		16316	02778
Ensembl ID		ENSG00000125170	ENSG00000170581
Uniprot IDs		H3BQ19 Q8TEW6	A0A494C164 P52630 R9QE65
PDB IDs			2KA4 6UX2 6WCZ 8T12 8T13
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Ephrin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Developmental Process Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Positive Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Receptor Complex Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Dendritic Spine Maintenance Positive Regulation Of Locomotion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Shape Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Binding Signal Transduction Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Adhesion ERBB2 Signaling Pathway Protein Phosphorylation	Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization Interferon-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Protein Localization Type I Interferon-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Response To Virus Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway P53 Binding Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Cellular Response To Virus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Interleukin-3 Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Response To Cytokine Tau Protein Binding Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of RNA Metabolic Process Transcription Coactivator Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Developmental Process Regulation Of Cellular Response To Heat Chromatin Remodeling Regulation Of Metabolic Process
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