NOTCH2NL and CSF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NOTCH2NL	CSF1
Gene Name		notch 2 N-terminal like	colony stimulating factor 1 (macrophage)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation	Ossification Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Developmental Process Involved In Reproduction Inflammatory Response Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Hemopoiesis Cell Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organism Growth Monocyte Activation Odontogenesis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587	10 interactors: CSF1R FHL3 GAB3 HLA-B NOTCH2NL PIK3R2 SGTA SLA2 SOCS1 TNF
Entrez ID		388677	1435
HPRD ID		14833	00388
Ensembl ID		ENSG00000213240	ENSG00000184371
Uniprot IDs		Q7Z3S9	P09603
PDB IDs			1HMC 3UEZ 3UF2 4ADF 4FA8
Enriched GO Terms of Interacting Partners?		Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin	Immune Response Immune System Process Regulation Of Immune Response Myeloid Leukocyte Differentiation Cytokine-mediated Signaling Pathway Macrophage Differentiation Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Response To Cytokine Myeloid Cell Differentiation Positive Regulation Of Chemokine Production Osteoclast Differentiation Innate Immune Response Regulation Of Kinase Activity Regulation Of Chemokine Production Cellular Response To Amino Acid Stimulus Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cytokine Secretion Regulation Of Transcription Factor Import Into Nucleus Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Interleukin-6 Production Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Ketone Metabolic Process Response To Amino Acid Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response
Tagcloud ?		a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures	bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1
Tagcloud (Difference) ?		a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures	bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1
Tagcloud (Intersection) ?