NOTCH2NL and PCSK5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NOTCH2NL	PCSK5
Gene Name		notch 2 N-terminal like	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm	Extracellular Space Golgi Apparatus Golgi Lumen Integral Component Of Membrane Secretory Granule
	Molecular Function	Calcium Ion Binding	Serine-type Endopeptidase Activity Peptidase Activity Peptide Binding
	Biological Process	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Skeletal System Development
Pathways			Signalling by NGF NGF processing
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728) Height ( 20881960 23563607) Metabolite levels (5-HIAA) ( 23319000) Response to fenofibrate (adiponectin levels) ( 23149075) Total ventricular volume ( 21116278)
Protein-Protein Interactions		241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587	20 interactors: AMH APPBP2 ATN1 CACNA1A GLRX3 HOXA1 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NL NUFIP2 PMCH PTPRM REN STK16
Entrez ID		388677	5125
HPRD ID		14833	08985
Ensembl ID		ENSG00000213240	ENSG00000099139
Uniprot IDs		Q7Z3S9	Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?		Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin	Developmental Process Multicellular Organismal Development Pons Development Cell Differentiation Anatomical Structure Development Organ Development System Development Tissue Development Behavior Neural Nucleus Development Optokinetic Behavior Cerebellar Molecular Layer Development Abducens Nerve Formation Neuron Death Vestibular Nucleus Development Facial Nucleus Development Preantral Ovarian Follicle Growth Urogenital System Development Feeding Behavior Positive Regulation Of Gene Expression Rhombomere 4 Development Cerebellum Maturation Semicircular Canal Formation Musculoskeletal Movement, Spinal Reflex Action Anatomical Structure Morphogenesis Rhombomere 3 Development Rhombomere 5 Development Gamma-aminobutyric Acid Secretion Renin-angiotensin Regulation Of Aldosterone Production Metencephalon Development Neuromuscular Process Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Response To Drug Rhythmic Synaptic Transmission Somite Specification Ectodermal Cell Differentiation Cell Development Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Oogenesis Stage Cell Projection Organization Drinking Behavior Gonadal Mesoderm Development Response To CGMP Mullerian Duct Regression Hindbrain Development Cell Morphogenesis Involved In Neuron Differentiation Calcium Ion-dependent Exocytosis Of Neurotransmitter
Tagcloud ?		a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Difference) ?		a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Intersection) ?