REL and TBP

Number of citations of the paper that reports this interaction (PubMedID 8413269)
47

Data Source:
HPRD (in vitro)

		REL	TBP
Description		REL proto-oncogene, NF-kB subunit	TATA-box binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol NF-kappaB Complex	Chromatin Euchromatin Male Germ Cell Nucleus Female Germ Cell Nucleus Female Pronucleus Male Pronucleus Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Cytosol Protein-containing Complex Pronucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding TFIIB-class Transcription Factor Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of DNA-templated Transcription Inflammatory Response Canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase III Spermatogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Activation of NF-kappaB in B cells	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression
Drugs
Diseases		Hodgkin lymphoma	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 22170493 26626624) Rheumatoid arthritis ( 19503088 30423114 24390342 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Ulcerative colitis ( 20228799)	Type 1 diabetes ( 21980299)
Interacting Genes		319 interacting genes: A1CF AAAS ACBD4 ACOT12 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 AIRIM AKT2 ALOX5 AQP1 AR ARFIP2 ARIH2 ARL16 ARMC7 ARNT2 ASAP3 ASMTL ATG9A ATP6V0D2 ATP6V1C2 ATPAF2 ATXN1 BANP BARHL2 BBS4 BCL2L15 BCL6 BID BLTP2 BMF C11orf68 C12orf75 C14orf119 C1orf50 C1orf56 C1orf74 C9orf72 CABP5 CACNA1S CALM1 CCNC CCNE1 CCNJL CDK18 CDKN1A CDKN2C CDKN2D CDR2L CENPX CEP19 CFAP206 CGGBP1 CHAF1A CHCHD2 CHIC2 CIB3 CINP CKS1B CLIC4 CLIP1 COL20A1 COL8A1 CPNE2 CPNE7 CPSF1 CSNK2A1 CTNNA3 CTNNBIP1 CXCL14 CYB5R2 DAAM2 DDX6 DEF6 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EHHADH EIF3A EIF3D EIF4A3 EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EMD EML2 EP300 EPHB6 EPM2AIP1 ESRRA ESRRG EXOSC1 EXOSC5 EXOSC8 FAAP20 FAM200C FAM90A1 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FNDC3B FOXO4 GADD45G GLYCTK GPKOW GRAP GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPF HNRNPLL HSD17B14 HSPA4 HSPA8 HSPB7 IL36RN KCTD6 KCTD7 KLHL32 KLHL40 KLHL42 KRTAP9-4 L3MBTL2 LASP1 LENG1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MAPRE3 MB21D2 MBD3 MEMO1 MID2 MIEN1 MIPOL1 MLIP MMP2 MORF4L1 MORF4L2 MRPL10 MSRB3 MTPN MTURN MVP MYO15B NABP1 NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NMRK1 NOL9 NOTCH1 NOXA1 NR2C2AP NUCB1 NUDT10 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PADI3 PAK1IP1 PARVG PATE1 PCYT2 PELI2 PGAP6 PICK1 PIH1D2 PLCB4 PLEKHN1 PM20D2 POFUT4 POLE2 POLR2L POP5 PPP4C PRDM10 PRKAA2 PRKAB2 PRKN PRPF31 PSMA1 PSMA4 PSMB8 PSORS1C2 PTGER3 PTK6 QARS1 R3HDM2 RAB29 RAB41 RABIF RAD23A RAD51D RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 RTL8C RUNX1T1 S100A1 SAMD11 SAT1 SCNM1 SDCBP SEC14L4 SEC31A SEPTIN7 SHC3 SIN3A SIX1 SLC39A13 SLC41A3 SLC6A12 SMG9 SNRNP25 SP1 SPATC1L SPG21 SPRY1 SRF STAMBPL1 STK16 SULT2B1 SUOX SZT2 TBC1D21 TBC1D22B TBP TCL1A TCP11L1 TDO2 THOC1 TLE5 TLX3 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRAPPC6A TRIM27 TRIM68 TRIM74 TSC22D3 TSEN15 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBASH3B UBE2D4 UBE2K UBE2Z UBXN7 VPS25 WNK3 YARS1 YJU2 ZBTB16 ZDHHC24 ZIC1 ZNF417 ZNF446 ZNF550 ZNF564 ZNF572 ZNF688 ZNF76 ZNF765	119 interacting genes: ABT1 AHR AR ATF4 BCL3 BRF1 BRF2 BTAF1 CAND2 CFTR CITED2 COL26A1 CREG1 CREM CTBP1 CTCFL CXXC1 DHX9 DR1 DRAP1 E2F1 EDF1 ELF3 ESR1 ETS1 FATE1 FOS FOXF2 GOLGA2 GTF2A1 GTF2A1L GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 GTF3C2 GTF3C3 GTF3C4 GTF3C5 H3-4 HAP1 HMBOX1 HMGB1 HNF4A HNRNPK HSF1 HTT HUWE1 IKZF1 JUN JUND JUP KDM5A KLF5 MBD2 MCM2 MDM2 MSX1 MYC NACA NCAPH NCOA1 NCOA3 NCOA6 NFE2L2 NFYB NFYC NR3C1 PAX3 PAX5 PAX6 PIAS1 PIAS3 POLR3F POU2F1 POU2F2 POU3F2 PSMC2 RB1 REL RELA REST RNF4 RUVBL1 RUVBL2 RXRA SERPINB5 SNAPC1 SNAPC2 SNAPC4 SP1 SPI1 SPIB SSX2IP SUB1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF1A TAF1B TAF1C TAF1L TAF5 TAF7L TCF12 TEAD1 TP53 TRAM2 TRIP4 UBE2I UBTF WDR62 YEATS2 YWHAE ZNF76
Entrez ID		5966	6908
HPRD ID		01286	02511
Ensembl ID		ENSG00000162924	ENSG00000112592
Uniprot IDs		A0A8V8TPL7 Q04864	P20226 Q32MN7
PDB IDs			1C9B 1CDW 1JFI 1NVP 1TGH 4ROC 4ROD 4ROE 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5N9G 6MZD 6MZL 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8ITY 8IUE 8IUH 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Nucleic Acid Metabolic Process I-kappaB/NF-kappaB Complex Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Macromolecule Metabolic Process Spliceosomal Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm TBP-class Protein Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process RNA Metabolic Process Chromatin Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Factor TFIID Complex Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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