REL and CLIC4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		REL	CLIC4
Description		REL proto-oncogene, NF-kB subunit	chloride intracellular channel 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol NF-kappaB Complex	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Cell-cell Junction Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Nuclear Matrix Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of DNA-templated Transcription Inflammatory Response Canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II	Angiogenesis Endothelial Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Vacuolar Acidification Fertilization Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Monoatomic Ion Transmembrane Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Branching Morphogenesis Of An Epithelial Tube Regulation Of Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Cellular Response To Calcium Ion Chloride Transmembrane Transport
Pathways		Activation of NF-kappaB in B cells
Drugs
Diseases		Hodgkin lymphoma
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 22170493 26626624) Rheumatoid arthritis ( 19503088 30423114 24390342 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Ulcerative colitis ( 20228799)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Height ( 20881960) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)
Interacting Genes		319 interacting genes: A1CF AAAS ACBD4 ACOT12 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 AIRIM AKT2 ALOX5 AQP1 AR ARFIP2 ARIH2 ARL16 ARMC7 ARNT2 ASAP3 ASMTL ATG9A ATP6V0D2 ATP6V1C2 ATPAF2 ATXN1 BANP BARHL2 BBS4 BCL2L15 BCL6 BID BLTP2 BMF C11orf68 C12orf75 C14orf119 C1orf50 C1orf56 C1orf74 C9orf72 CABP5 CACNA1S CALM1 CCNC CCNE1 CCNJL CDK18 CDKN1A CDKN2C CDKN2D CDR2L CENPX CEP19 CFAP206 CGGBP1 CHAF1A CHCHD2 CHIC2 CIB3 CINP CKS1B CLIC4 CLIP1 COL20A1 COL8A1 CPNE2 CPNE7 CPSF1 CSNK2A1 CTNNA3 CTNNBIP1 CXCL14 CYB5R2 DAAM2 DDX6 DEF6 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EHHADH EIF3A EIF3D EIF4A3 EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EMD EML2 EP300 EPHB6 EPM2AIP1 ESRRA ESRRG EXOSC1 EXOSC5 EXOSC8 FAAP20 FAM200C FAM90A1 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FNDC3B FOXO4 GADD45G GLYCTK GPKOW GRAP GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPF HNRNPLL HSD17B14 HSPA4 HSPA8 HSPB7 IL36RN KCTD6 KCTD7 KLHL32 KLHL40 KLHL42 KRTAP9-4 L3MBTL2 LASP1 LENG1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MAPRE3 MB21D2 MBD3 MEMO1 MID2 MIEN1 MIPOL1 MLIP MMP2 MORF4L1 MORF4L2 MRPL10 MSRB3 MTPN MTURN MVP MYO15B NABP1 NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NMRK1 NOL9 NOTCH1 NOXA1 NR2C2AP NUCB1 NUDT10 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PADI3 PAK1IP1 PARVG PATE1 PCYT2 PELI2 PGAP6 PICK1 PIH1D2 PLCB4 PLEKHN1 PM20D2 POFUT4 POLE2 POLR2L POP5 PPP4C PRDM10 PRKAA2 PRKAB2 PRKN PRPF31 PSMA1 PSMA4 PSMB8 PSORS1C2 PTGER3 PTK6 QARS1 R3HDM2 RAB29 RAB41 RABIF RAD23A RAD51D RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 RTL8C RUNX1T1 S100A1 SAMD11 SAT1 SCNM1 SDCBP SEC14L4 SEC31A SEPTIN7 SHC3 SIN3A SIX1 SLC39A13 SLC41A3 SLC6A12 SMG9 SNRNP25 SP1 SPATC1L SPG21 SPRY1 SRF STAMBPL1 STK16 SULT2B1 SUOX SZT2 TBC1D21 TBC1D22B TBP TCL1A TCP11L1 TDO2 THOC1 TLE5 TLX3 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRAPPC6A TRIM27 TRIM68 TRIM74 TSC22D3 TSEN15 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBASH3B UBE2D4 UBE2K UBE2Z UBXN7 VPS25 WNK3 YARS1 YJU2 ZBTB16 ZDHHC24 ZIC1 ZNF417 ZNF446 ZNF550 ZNF564 ZNF572 ZNF688 ZNF76 ZNF765	8 interacting genes: ACTB CLIC6 DNM1 ERCC6 HSP90AB1 REL TPRN YWHAZ
Entrez ID		5966	25932
HPRD ID		01286	05943
Ensembl ID		ENSG00000162924	ENSG00000169504
Uniprot IDs		A0A8V8TPL7 Q04864	Q6FIC5 Q9Y696
PDB IDs			2AHE 2D2Z 3OQS
Enriched GO Terms of Interacting Partners?		Protein Binding Cytosol Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Nucleic Acid Metabolic Process I-kappaB/NF-kappaB Complex Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Macromolecule Metabolic Process Spliceosomal Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination	Nitric-oxide Synthase Regulator Activity Protein Kinase Binding Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein HSP90-CDC37 Chaperone Complex Melanosome Synaptic Target Recognition Protein Phosphatase Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Extracellular Exosome Blood Microparticle Transporter Regulator Activity D2 Dopamine Receptor Binding Stereocilium Maintenance Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Chromaffin Granule NF-kappaB Complex Stereocilium Base Regulation Of Double-strand Break Repair Protein Localization To Adherens Junction Dense Body Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Golgi Reassembly Nucleoplasm Morphogenesis Of A Polarized Epithelium Response To Superoxide Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Vesicle DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical ATP-dependent Protein Binding B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
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