REL and ADRB2

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		REL	ADRB2
Gene Name		v-rel avian reticuloendotheliosis viral oncogene homolog	adrenoceptor beta 2, surface
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex Cytosol I-kappaB/NF-kappaB Complex	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 22412388 21102463) Hodgkin's lymphoma ( 21037568) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190) Psoriatic arthritis ( 22170493) Rheumatoid arthritis ( 20453842 19503088) Ulcerative colitis ( 20228799)
Protein-Protein Interactions		201 interactors: A1CF AAAS ACOT8 ACTN3 ADRB2 ADSL AES AGPAT4 ALOX5 AR ARIH2 ARNT2 ASAP3 ATG9A ATPAF2 ATXN1 BARHL2 BID BMF BZRAP1 C11orf68 C12orf75 C1orf109 C20orf195 C9orf72 C9orf91 CABP5 CALM1 CCNE1 CCNJL CDKN2C CEP19 CGGBP1 CHAF1A CHCHD2 CIB3 CINP CKS1B CLIC4 COL20A1 COL8A1 CPNE2 CPSF1 CTNNBIP1 CXCL14 DAAM2 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EGLN3 EIF3A EIF3D EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EML2 EP300 EPHB6 EPM2AIP1 EXOSC1 EXOSC5 EXOSC8 FHIT FHL2 FKBP1B FLAD1 FLNA FOXO4 FUT11 GADD45G GLYCTK GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HSPA4 HSPA8 HSPB7 IL36RN KIAA0100 KLHL32 KLHL40 KRTAP9-4 LASP1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MEMO1 MIEN1 MORF4L1 MRPL10 MTPN MVP NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NOL9 NOTCH1 NR2C2AP NUCB1 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PARK2 PARVG PATE1 PIH1D2 PLCB4 PLEKHN1 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAB2 PSMA1 PTGER3 PTK6 R3HDM2 RAB41 RABIF RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RSPH14 SAT1 SDCBP SEC14L4 SEC31A SEPT7 SIN3A SLC39A13 SLC41A3 SLC6A12 SNRNP25 SP1 SRF STK16 STRA13 SZT2 TBP TDO2 TMEM165 TMEM8A TNIP2 TNS2 TRAPPC2L TRIM74 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBE2K UBE2Z VPS25 ZDHHC24 ZNF417 ZNF550 ZNF564 ZNF572 ZNF765	88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		5966	154
HPRD ID		01286	00187
Ensembl ID		ENSG00000162924	ENSG00000169252
Uniprot IDs		Q04864 Q17RU2	P07550
PDB IDs			1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor 9 Signaling Pathway Apoptotic Process Cell Death Toll-like Receptor 3 Signaling Pathway Death Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Type I Interferon Production Regulation Of RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Posttranscriptional Regulation Of Gene Expression Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process	Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations sarcoma slk transferase triphosphate tunel y	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Difference) ?		chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations sarcoma slk transferase triphosphate tunel y	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Intersection) ?