REL and PSMA1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		REL	PSMA1
Name		REL proto-oncogene, NF-kB subunit	proteasome 20S subunit alpha 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol NF-kappaB Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Lipopolysaccharide Binding Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of DNA-templated Transcription Inflammatory Response Canonical NF-kappaB Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II	Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Activation of NF-kappaB in B cells	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		None	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases		Hodgkin lymphoma	None
GWAS		Celiac disease ( 20190752 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Crohn's disease ( 22412388 21102463 ) Erectile dysfunction ( 30583798 ) Hodgkin's lymphoma ( 21037568 24920014 ) Inflammatory bowel disease ( 23128233 ) Psoriasis ( 20953190 23143594 25574825 25903422 ) Psoriasis vulgaris ( 26626624 ) Psoriatic arthritis ( 22170493 26626624 ) Rheumatoid arthritis ( 19503088 30423114 24390342 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Ulcerative colitis ( 20228799 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Bipolar disorder ( 31043756 ) Diastolic blood pressure ( 27841878 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HDL cholesterol levels ( 32203549 ) High chromosomal aberration frequency (total) ( 31586183 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Skin and soft tissue infections ( 33662382 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 32154731 32203549 ) Vitamin D levels ( 25208829 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		319 interacting genes: A1CF AAAS ACBD4 ACOT12 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 AIRIM AKT2 ALOX5 AQP1 AR ARFIP2 ARIH2 ARL16 ARMC7 ARNT2 ASAP3 ASMTL ATG9A ATP6V0D2 ATP6V1C2 ATPAF2 ATXN1 BANP BARHL2 BBS4 BCL2L15 BCL6 BID BLTP2 BMF C11orf68 C12orf75 C14orf119 C1orf50 C1orf56 C1orf74 C9orf72 CABP5 CACNA1S CALM1 CCNC CCNE1 CCNJL CDK18 CDKN1A CDKN2C CDKN2D CDR2L CENPX CEP19 CFAP206 CGGBP1 CHAF1A CHCHD2 CHIC2 CIB3 CINP CKS1B CLIC4 CLIP1 COL20A1 COL8A1 CPNE2 CPNE7 CPSF1 CSNK2A1 CTNNA3 CTNNBIP1 CXCL14 CYB5R2 DAAM2 DDX6 DEF6 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EHHADH EIF3A EIF3D EIF4A3 EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EMD EML2 EP300 EPHB6 EPM2AIP1 ESRRA ESRRG EXOSC1 EXOSC5 EXOSC8 FAAP20 FAM200C FAM90A1 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FNDC3B FOXO4 GADD45G GLYCTK GPKOW GRAP GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPF HNRNPLL HSD17B14 HSPA4 HSPA8 HSPB7 IL36RN KCTD6 KCTD7 KLHL32 KLHL40 KLHL42 KRTAP9-4 L3MBTL2 LASP1 LENG1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MAPRE3 MB21D2 MBD3 MEMO1 MID2 MIEN1 MIPOL1 MLIP MMP2 MORF4L1 MORF4L2 MRPL10 MSRB3 MTPN MTURN MVP MYO15B NABP1 NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NMRK1 NOL9 NOTCH1 NOXA1 NR2C2AP NUCB1 NUDT10 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PADI3 PAK1IP1 PARVG PATE1 PCYT2 PELI2 PGAP6 PICK1 PIH1D2 PLCB4 PLEKHN1 PM20D2 POFUT4 POLE2 POLR2L POP5 PPP4C PRDM10 PRKAA2 PRKAB2 PRKN PRPF31 PSMA1 PSMA4 PSMB8 PSORS1C2 PTGER3 PTK6 QARS1 R3HDM2 RAB29 RAB41 RABIF RAD23A RAD51D RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 RTL8C RUNX1T1 S100A1 SAMD11 SAT1 SCNM1 SDCBP SEC14L4 SEC31A SEPTIN7 SHC3 SIN3A SIX1 SLC39A13 SLC41A3 SLC6A12 SMG9 SNRNP25 SP1 SPATC1L SPG21 SPRY1 SRF STAMBPL1 STK16 SULT2B1 SUOX SZT2 TBC1D21 TBC1D22B TBP TCL1A TCP11L1 TDO2 THOC1 TLE5 TLX3 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRAPPC6A TRIM27 TRIM68 TRIM74 TSC22D3 TSEN15 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBASH3B UBE2D4 UBE2K UBE2Z UBXN7 VPS25 WNK3 YARS1 YJU2 ZBTB16 ZDHHC24 ZIC1 ZNF417 ZNF446 ZNF550 ZNF564 ZNF572 ZNF688 ZNF76 ZNF765	173 interacting genes: ABCD3 ABI2 ABI3 ACTN1 ACTN2 AGR2 APIP APP BANF2 BLZF1 C22orf39 CABP5 CALCOCO2 CBS CCDC102B CCDC136 CCDC85B CCNH CDA CDKN2D CDR2 CEBPA CEP70 CEP72 CFAP206 CHMP1A CINP CIP2A COG4 COG6 COIL CRX CSTPP1 DCTD DCTPP1 DDIT4L DEF6 DLEU1 DRC12 DYDC1 DYNLT1 EHMT2 EIF4A3 EMSY ERBB2 FNDC11 GNPTAB GOLGA2 GOLGA6A GPHN GSDMD GUCD1 HEXIM2 HOMER3 HOMEZ HOOK2 HOXC11 HSD17B14 HSF2BP IFT20 IKZF1 IKZF3 INO80E IPO13 KAZN KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS3 KRT13 KRT15 KRT19 KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP4-1 KRTAP5-9 KRTAP6-3 LDB1 LDOC1 LINC00632 LMO2 LONRF1 LZTFL1 LZTS1 LZTS2 MAD1L1 MAPK1 MAPRE1 MAPRE3 MCM6 MDH2 MID2 MIEF1 MKNK2 MKRN3 MLH1 MRFAP1L1 MSANTD4 MT-CO2 MTUS2 NAB2 NBPF19 NECAB2 NME7 NMI NOP53 NOTCH2NLA PCBD1 PCYT2 PICK1 PLK1 PM20D2 PNMA1 PNMA2 PNMA5 POLR1C PPCDC PRDM14 PRIMPOL PRKN PRPH PSMA2 PSMA3 PSMA4 PSMA7 PSMB10 PSMB2 PSMB5 RAD54B RBCK1 REL RFC2 RGS19 ROPN1 SAT1 SFMBT1 SH3BP4 SH3GLB1 SLF2 SNCA SPDEF SSX2IP TCF12 TCF4 TDO2 TEKT4 TNFAIP1 TNR TRAF1 TRAF5 TRIM10 TRIM23 TRIM27 TRIM42 TRIM54 TSC22D4 UBD UBXN11 VCP VIM VMAC WTAP YPEL5 ZFAND1 ZMYND19
Entrez ID		5966	5682
HPRD ID		01286	04170
Ensembl ID		ENSG00000162924	ENSG00000129084
Uniprot IDs		A0A8V8TPL7 Q04864	B4E0X6 P25786
PDB IDs		Not available	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN
GO Terms Enriched among Interactors		Protein Binding Cytosol Nucleus Nucleoplasm Cytoplasm Identical Protein Binding Nucleic Acid Metabolic Process I-kappaB/NF-kappaB Complex Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Macromolecule Metabolic Process Spliceosomal Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination	Identical Protein Binding Protein Binding Cytoskeleton Intermediate Filament Proteasome Core Complex Keratin Filament Intermediate Filament Organization Structural Constituent Of Skin Epidermis Cytoplasm Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Proteasome Complex Cytosol Protein Homooligomerization Proteasome Core Complex, Alpha-subunit Complex Protein Complex Oligomerization Cytoskeleton Organization Protein Domain Specific Binding Aggresome Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding Regulation Of Microtubule-based Process Inclusion Body Assembly Cytosine Metabolic Process Structural Molecule Activity Positive Regulation Of Protein K63-linked Deubiquitination Cullin Family Protein Binding Nucleus Proteasome Core Complex, Beta-subunit Complex Microtubule-based Process Positive Regulation Of Organelle Organization Ficolin-1-rich Granule Lumen Regulation Of Microtubule Cytoskeleton Organization Type III Intermediate Filament Cellular Response To Arsenite Ion Lung Goblet Cell Differentiation Mitotic Spindle Astral Microtubule End Protein Localization To Microtubule Centrosome Proteasomal Protein Catabolic Process Cellular Component Assembly Glial Cell Development Mitotic Spindle Pole Proteolysis Involved In Protein Catabolic Process Pseudopodium Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway