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REL and POLR2L
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
REL
POLR2L
Description
REL proto-oncogene, NF-kB subunit
RNA polymerase II, I and III subunit L
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
NF-kappaB Complex
DNA-directed RNA Polymerase Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
RNA Polymerase III Complex
Nucleolus
RNA Polymerase I Complex
Cytosol
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
DNA Binding
DNA-directed RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Cytokine Production
Regulation Of DNA-templated Transcription
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Gene Expression
Negative Regulation Of Interferon-beta Production
Response To Cytokine
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase I
Transcription By RNA Polymerase I
Transcription By RNA Polymerase II
TRNA Transcription By RNA Polymerase III
Pathways
Activation of NF-kappaB in B cells
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Diseases
Hodgkin lymphoma
GWAS
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
22412388
21102463
)
Erectile dysfunction (
30583798
)
Hodgkin's lymphoma (
21037568
24920014
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
20953190
23143594
25574825
25903422
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
22170493
26626624
)
Rheumatoid arthritis (
19503088
30423114
24390342
23143596
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Ulcerative colitis (
20228799
)
Pulse pressure (
30578418
)
Interacting Genes
319 interacting genes:
A1CF
AAAS
ACBD4
ACOT12
ACOT8
ACTN3
ADRB2
ADSL
AGPAT4
AIRIM
AKT2
ALOX5
AQP1
AR
ARFIP2
ARIH2
ARL16
ARMC7
ARNT2
ASAP3
ASMTL
ATG9A
ATP6V0D2
ATP6V1C2
ATPAF2
ATXN1
BANP
BARHL2
BBS4
BCL2L15
BCL6
BID
BLTP2
BMF
C11orf68
C12orf75
C14orf119
C1orf50
C1orf56
C1orf74
C9orf72
CABP5
CACNA1S
CALM1
CCNC
CCNE1
CCNJL
CDK18
CDKN1A
CDKN2C
CDKN2D
CDR2L
CENPX
CEP19
CFAP206
CGGBP1
CHAF1A
CHCHD2
CHIC2
CIB3
CINP
CKS1B
CLIC4
CLIP1
COL20A1
COL8A1
CPNE2
CPNE7
CPSF1
CSNK2A1
CTNNA3
CTNNBIP1
CXCL14
CYB5R2
DAAM2
DDX6
DEF6
DGCR6
DHPS
DMRT3
DNTT
DPF2
DYNC1LI1
EFHC1
EHHADH
EIF3A
EIF3D
EIF4A3
EIF4E2
EIF4EBP1
EIF5A
EIF5A2
ELF1
EMD
EML2
EP300
EPHB6
EPM2AIP1
ESRRA
ESRRG
EXOSC1
EXOSC5
EXOSC8
FAAP20
FAM200C
FAM90A1
FHIT
FHL2
FKBP1B
FLAD1
FLNA
FNDC11
FNDC3B
FOXO4
GADD45G
GLYCTK
GPKOW
GRAP
GRB2
GTF2B
HAT1
HDAC7
HIP1
HLA-DOA
HNRNPF
HNRNPLL
HSD17B14
HSPA4
HSPA8
HSPB7
IL36RN
KCTD6
KCTD7
KLHL32
KLHL40
KLHL42
KRTAP9-4
L3MBTL2
LASP1
LENG1
LGALS14
LMO1
LMO2
LNPEP
LSM2
MAD2L2
MAGOHB
MAP3K7CL
MAP3K8
MAPK8
MAPRE3
MB21D2
MBD3
MEMO1
MID2
MIEN1
MIPOL1
MLIP
MMP2
MORF4L1
MORF4L2
MRPL10
MSRB3
MTPN
MTURN
MVP
MYO15B
NABP1
NAGK
NCK2
NDE1
NDUFAF3
NECAP1
NEDD9
NEIL2
NEUROG3
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NGB
NKRF
NME7
NMRK1
NOL9
NOTCH1
NOXA1
NR2C2AP
NUCB1
NUDT10
NUDT14
NXT2
OAZ3
OSGIN1
OSTF1
OTUB2
OTUD4
PADI3
PAK1IP1
PARVG
PATE1
PCYT2
PELI2
PGAP6
PICK1
PIH1D2
PLCB4
PLEKHN1
PM20D2
POFUT4
POLE2
POLR2L
POP5
PPP4C
PRDM10
PRKAA2
PRKAB2
PRKN
PRPF31
PSMA1
PSMA4
PSMB8
PSORS1C2
PTGER3
PTK6
QARS1
R3HDM2
RAB29
RAB41
RABIF
RAD23A
RAD51D
RASSF5
RBM39
RECK
RELA
REXO1L6P
RIPPLY1
RNF213
RNF6
RSPH14
RTL8C
RUNX1T1
S100A1
SAMD11
SAT1
SCNM1
SDCBP
SEC14L4
SEC31A
SEPTIN7
SHC3
SIN3A
SIX1
SLC39A13
SLC41A3
SLC6A12
SMG9
SNRNP25
SP1
SPATC1L
SPG21
SPRY1
SRF
STAMBPL1
STK16
SULT2B1
SUOX
SZT2
TBC1D21
TBC1D22B
TBP
TCL1A
TCP11L1
TDO2
THOC1
TLE5
TLX3
TMEM165
TMEM268
TNIP2
TNS2
TRAPPC2L
TRAPPC6A
TRIM27
TRIM68
TRIM74
TSC22D3
TSEN15
TSPOAP1
TSSC4
TSSK3
TSTD2
TTC19
TTC21A
TXNL4B
UBASH3A
UBASH3B
UBE2D4
UBE2K
UBE2Z
UBXN7
VPS25
WNK3
YARS1
YJU2
ZBTB16
ZDHHC24
ZIC1
ZNF417
ZNF446
ZNF550
ZNF564
ZNF572
ZNF688
ZNF76
ZNF765
27 interacting genes:
AGR2
BANP
CCDC85B
CCN3
CHEK2
COIL
EXOSC5
FAM217B
L3MBTL3
NACC1
NFKBIB
PHC2
POLR2A
POLR2B
POLR2C
POLR2D
POLR2E
POLR2H
PSMA6
REL
RPAP1
SNX7
SPAG5
THAP1
TP53BP2
TRIP13
ZBTB14
Entrez ID
5966
5441
HPRD ID
01286
01155
Ensembl ID
ENSG00000162924
ENSG00000177700
Uniprot IDs
A0A8V8TPL7
Q04864
P62875
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
6XRE
7A6H
7AE1
7AE3
7AEA
7AST
7D58
7D59
7DN3
7DU2
7FJI
7FJJ
7LBM
7OB9
7OBA
7OBB
7VBA
7VBB
7VBC
8A43
8ITY
8IUE
8IUH
9EHZ
9EI1
9EI3
9EI4
9FSO
9FSP
9FSQ
9FSR
9FSS
Enriched GO Terms of Interacting Partners
?
Protein Binding
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Identical Protein Binding
Nucleic Acid Metabolic Process
I-kappaB/NF-kappaB Complex
Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Binding
Macromolecule Metabolic Process
Spliceosomal Complex
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein K6-linked Ubiquitination
RNA Polymerase II, Core Complex
DNA-directed RNA Polymerase Complex
DNA-templated Transcription
DNA-directed RNA Polymerase Activity
Transcription By RNA Polymerase II
Nucleobase-containing Compound Biosynthetic Process
Nucleoplasm
RNA Metabolic Process
RNA-directed RNA Polymerase Activity
RNA-templated Transcription
DNA Binding
Nucleus
Nucleic Acid Metabolic Process
Macromolecule Biosynthetic Process
5'-3' RNA Polymerase Activity
Nucleobase-containing Compound Metabolic Process
RNA Polymerase I Complex
RNA Polymerase III Complex
Nucleotidyltransferase Activity
Positive Regulation Of Organelle Assembly
Nucleolus
Positive Regulation Of Autophagosome Assembly
Positive Regulation Of Vacuole Organization
NF-kappaB Binding
Identical Protein Binding
Purine Ribonucleoside Triphosphate Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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