RGL3 and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RGL3	RRAS2
Description		ral guanine nucleotide dissociation stimulator like 3	RAS related 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction	Osteoblast Differentiation Signal Transduction Ras Protein Signal Transduction Cell Migration Schwann Cell Migration Positive Regulation Of Schwann Cell Migration
Pathways		RAF/MAP kinase cascade	RND1 GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27618448 27841878) Hypertension ( 27618447 27618448 32709000 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 30578418 27618448 27618447)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2	33 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 LINC00632 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		57139	22800
HPRD ID		18844	02518
Ensembl ID		ENSG00000205517	ENSG00000133818
Uniprot IDs		Q3MIN7	P62070
PDB IDs			2ERY 9B4Q 9B4S
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction GDP Binding Small GTPase-mediated Signal Transduction G Protein Activity GTPase Activity GTP Binding Intracellular Signaling Cassette Hydrolase Activity Dendritic Tree Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Intracellular Signal Transduction Calmodulin Binding MAPK Cascade Neural Crest Formation Positive Regulation Of Glial Cell Migration Regulation Of Cdc42 Protein Signal Transduction Signal Transduction	Guanyl-nucleotide Exchange Factor Activity Intracellular Signaling Cassette Signal Transduction Ras Protein Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death SMAD Binding Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Apoptotic Signaling Pathway Small GTPase-mediated Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Bone Mineralization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Small GTPase Binding Regulation Of Protein Modification Process Intracellular Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To BMP Stimulus Response To Growth Factor Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Regulation Of Cell Population Proliferation Protein Prenyltransferase Activity Apoptotic Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Endothelial Cell Development
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