MRPL10 and USP22

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)

		MRPL10	USP22
Gene Name		mitochondrial ribosomal protein L10	ubiquitin specific peptidase 22
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribonucleoprotein Complex	SAGA Complex SAGA-type Complex
	Molecular Function	Structural Constituent Of Ribosome Poly(A) RNA Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Translation Organelle Organization Mitochondrial Translation Ribosome Biogenesis Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Chromatin Organization Transcription, DNA-templated Cell Cycle Embryo Development Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		7 interactors: APP FAM9B KLHL12 PNMA1 REL TCF4 USP22	9 interactors: AASDHPPT HEXA HIST2H2AC HIST2H2BE MRPL10 MRPL44 PSME1 SCFD1 UBC
Entrez ID		124995	23326
HPRD ID		14738	19411
Ensembl ID		ENSG00000159111	ENSG00000124422
Uniprot IDs		Q7Z7H8	Q9UPT9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Metabolic Process Maintenance Of DNA Repeat Elements Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Vesicle Localization Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Canonical Wnt Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Choice Point Recognition Embryonic Genitalia Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Myoblast Fate Commitment Wnt Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Developmental Growth Neuron Remodeling Secretory Granule Localization Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Hindgut Morphogenesis Immune Response Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Defense Response Hindgut Development Regulation Of Signaling Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process RNA Metabolic Process Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process	Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Translation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Autophagic Vacuole Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Translational Elongation Cellular Protein Complex Disassembly
Tagcloud ?		15k cdnas characters clustering developmentally dncic2 dosage ds eef1g eif3sf extra hchr21 hierarchical manifested mrps18a neurogenesis neuron neuropathological outgrowth patterned peg3 phenotypic retardation sf3a60 snapc3 srprb syngr2 tt2f ubce8	activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Difference) ?		15k cdnas characters clustering developmentally dncic2 dosage ds eef1g eif3sf extra hchr21 hierarchical manifested mrps18a neurogenesis neuron neuropathological outgrowth patterned peg3 phenotypic retardation sf3a60 snapc3 srprb syngr2 tt2f ubce8	activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Intersection) ?