POLA1 and CDC45

Number of citations of the paper that reports this interaction (PMID 10518787)
10

Data Source:
HPRD (in vitro)

		POLA1	CDC45
Gene Name		polymerase (DNA directed), alpha 1, catalytic subunit	cell division cycle 45
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Nuclear Matrix	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity DNA Primase Activity Protein Binding Protein Kinase Binding Metal Ion Binding Protein Heterodimerization Activity 4 Iron, 4 Sulfur Cluster Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Proliferation Viral Process Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of Chromatin Silencing At Telomere DNA Duplex Unwinding Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition G1/S-Specific Transcription Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Telomere C-strand synthesis initiation Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1	E2F mediated regulation of DNA replication Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex S Phase DNA strand elongation Cell Cycle, Mitotic Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Mitotic G1-G1/S phases Unwinding of DNA
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE RB1 RBMS1 SERPINA3 SMC1A TP53 XRCC5	16 interactors: CAMK1G CDK4 CDKN1A CDKN2A CEP55 MCM10 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TRAPPC3
Entrez ID		5422	8318
HPRD ID		02416	09145
Ensembl ID		ENSG00000101868	ENSG00000093009
Uniprot IDs		A6NMQ1 P09884	O75419
PDB IDs		1K0P 1K18 1N5G
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication Chromosome Organization Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA Conformation Change Positive Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Nuclear Division Regulation Of Cell Cycle Telomere Maintenance Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Nuclear DNA Replication Mitotic DNA Integrity Checkpoint Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Mitotic Cell Cycle DNA Strand Elongation G2/M Transition Of Mitotic Cell Cycle DNA Replication Initiation Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process DNA Replication Initiation DNA Replication Cell Cycle DNA-dependent DNA Replication DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Arrest Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Hyperoxia Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of B Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Organ Regeneration Cell Aging Cell Proliferation Positive Regulation Of Cell Cycle Arrest Leading Strand Elongation Regulation Of Fibroblast Proliferation Senescence-associated Heterochromatin Focus Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Division
Tagcloud ?			atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions
Tagcloud (Difference) ?			atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions
Tagcloud (Intersection) ?