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POLA1 and GINS4
Number of citations of the paper that reports this interaction (PubMedID
21705323
)
58
Data Source:
BioGRID
(pull down)
POLA1
GINS4
Description
DNA polymerase alpha 1, catalytic subunit
GINS complex subunit 4
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
GINS Complex
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
CMG Complex
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Nucleotidyltransferase Activity
Protein Kinase Binding
DNA Polymerase Activity
Metal Ion Binding
Protein Binding
Biological Process
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA-templated DNA Replication
DNA Replication, Synthesis Of Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Type I Interferon Production
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Double-strand Break Repair Via Break-induced Replication
Inner Cell Mass Cell Proliferation
DNA Replication
DNA-templated DNA Replication
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Defective pyroptosis
Unwinding of DNA
Unwinding of DNA
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Interacting Genes
18 interacting genes:
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
PRIM2
RAD51
RB1
RBMS1
SERPINA3
SMC1A
SUMO2
TP53
XRCC5
12 interacting genes:
-
BIN3
CTNNBIP1
DMAP1
GINS2
KIF16B
LHX8
PBX4
POLA1
POLD1
POLE
PPP1R13B
Entrez ID
5422
84296
HPRD ID
02416
11583
Ensembl ID
ENSG00000101868
ENSG00000147536
Uniprot IDs
A6NMQ1
P09884
Q9BRT9
PDB IDs
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
7N2M
7OPL
7U5C
8B9D
8D0B
8D0K
8D96
8D9D
8QJ7
8VY3
9C8V
9MJ5
2E9X
2EHO
2Q9Q
6XTX
6XTY
7PFO
7PLO
8B9D
8OK2
Enriched GO Terms of Interacting Partners
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DNA Metabolic Process
DNA Replication
DNA Repair
Nucleic Acid Metabolic Process
DNA-templated DNA Replication
DNA Damage Response
Nucleobase-containing Compound Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Chromosome Organization
DNA Replication, Synthesis Of Primer
Macromolecule Metabolic Process
Chromosome, Telomeric Region
Chromatin Binding
Regulation Of DNA Metabolic Process
Cellular Response To Stress
Nucleoplasm
Double-strand Break Repair
Regulation Of Chromosome Organization
Response To Gamma Radiation
Macromolecule Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Recombinational Repair
Chromosome
Cellular Response To Radiation
DNA Binding
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Double-strand Break Repair Via Homologous Recombination
Cell Cycle G1/S Phase Transition
Cyclin-dependent Protein Kinase Activity
DNA Replication Proofreading
DNA Biosynthetic Process
DNA Replication Initiation
Cellular Response To Gamma Radiation
Site Of Double-strand Break
Telomere Maintenance
Nucleus
Negative Regulation Of Cell Cycle Phase Transition
Protein Localization To Chromosome
PML Body
DNA Recombination
Alpha DNA Polymerase:primase Complex
Glial Cell Apoptotic Process
Response To Radiation
Regulation Of Cell Cycle Phase Transition
Telomere Organization
Histone Kinase Activity
Nucleotide-excision Repair, DNA Gap Filling
Negative Regulation Of Cell Cycle Process
4 Iron, 4 Sulfur Cluster Binding
Double-strand Break Repair Via Homologous Recombination
DNA Polymerase Activity
DNA-directed DNA Polymerase Activity
DNA Replication Proofreading
DNA Synthesis Involved In DNA Repair
Leading Strand Elongation
DNA Replication
DNA-templated DNA Replication
Nucleotide-excision Repair, DNA Gap Filling
DNA Repair
DNA Strand Elongation Involved In DNA Replication
Nucleotidyltransferase Activity
DNA Biosynthetic Process
Base-excision Repair, Gap-filling
DNA Strand Elongation
DNA Metabolic Process
DNA Damage Response
4 Iron, 4 Sulfur Cluster Binding
Actin Cortical Patch Localization
Regulation Of Vascular Permeability Involved In Acute Inflammatory Response
Iron-sulfur Cluster Binding
Beta-catenin-ICAT Complex
Indoleamine 2,3-dioxygenase Activity
Lagging Strand Elongation
DNA Synthesis Involved In UV-damage Excision Repair
Unidimensional Cell Growth
Tryptophan 2,3-dioxygenase Activity
Mitotic DNA Replication Initiation
Nucleobase-containing Compound Biosynthetic Process
Alpha DNA Polymerase:primase Complex
Error-free Translesion Synthesis
Delta DNA Polymerase Complex
Epsilon DNA Polymerase Complex
Single-stranded DNA 3'-5' DNA Exonuclease Activity
GINS Complex
Myoblast Migration Involved In Skeletal Muscle Regeneration
Response To Ethanol
L-tryptophan Catabolic Process To Kynurenine
Cellular Response To Stress
DNA Replication, Synthesis Of Primer
Nucleotide-excision Repair Complex
Negative Regulation Of DNA-templated Transcription Initiation
Negative Regulation Of Transcription Initiation By RNA Polymerase II
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Tagcloud (Difference)
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Tagcloud (Intersection)
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