POLA1 and POLA2

Number of citations of the paper that reports this interaction (PMID 8223465)
43

Data Source:
HPRD (in vitro, in vivo)

		POLA1	POLA2
Gene Name		polymerase (DNA directed), alpha 1, catalytic subunit	polymerase (DNA directed), alpha 2, accessory subunit
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Nuclear Matrix	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity DNA Primase Activity Protein Binding Protein Kinase Binding Metal Ion Binding Protein Heterodimerization Activity 4 Iron, 4 Sulfur Cluster Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Proliferation Viral Process Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition G1/S-Specific Transcription Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Telomere C-strand synthesis initiation Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1	Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs		Cladribine Clofarabine Fludarabine Nelarabine	Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE RB1 RBMS1 SERPINA3 SMC1A TP53 XRCC5	31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1
Entrez ID		5422	23649
HPRD ID		02416	10160
Ensembl ID		ENSG00000101868
Uniprot IDs		A6NMQ1 P09884	Q14181
PDB IDs		1K0P 1K18 1N5G	2KEB 4E2I
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication Chromosome Organization Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA Conformation Change Positive Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Nuclear Division Regulation Of Cell Cycle Telomere Maintenance Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Nuclear DNA Replication Mitotic DNA Integrity Checkpoint Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Mitotic Cell Cycle DNA Strand Elongation G2/M Transition Of Mitotic Cell Cycle DNA Replication Initiation Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport
Tagcloud ?			beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?			beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?