POLA1 and HELB

Number of citations of the paper that reports this interaction (PubMedID 12181327)
0

Data Source:
HPRD (in vitro, in vivo)

		POLA1	HELB
Description		DNA polymerase alpha 1, catalytic subunit	DNA helicase B
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Cytosol Nuclear Matrix	Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Cytoplasm Mitochondrion Cytosol Nuclear Body Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Protein Kinase Binding DNA Polymerase Activity Metal Ion Binding	Nucleotide Binding DNA Helicase Activity Helicase Activity ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Protein-containing Complex Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Repair DNA Damage Response Regulation Of DNA Double-strand Break Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Menopause (age at onset) ( 26414677) White blood cell count (basophil) ( 27863252 29403010)
Interacting Genes		18 interacting genes: CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	3 interacting genes: POLA1 POLA2 RPA1
Entrez ID		5422	92797
HPRD ID		02416	09979
Ensembl ID		ENSG00000101868	ENSG00000127311
Uniprot IDs		A6NMQ1 P09884	F5H1I4 Q8NG08
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7 7N2M 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V 9MJ5	7XV1
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication DNA Repair Nucleic Acid Metabolic Process DNA-templated DNA Replication DNA Damage Response Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromosome Organization DNA Replication, Synthesis Of Primer Macromolecule Metabolic Process Chromosome, Telomeric Region Chromatin Binding Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleoplasm Double-strand Break Repair Regulation Of Chromosome Organization Response To Gamma Radiation Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process Recombinational Repair Chromosome Cellular Response To Radiation DNA Binding G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Activity DNA Replication Proofreading DNA Biosynthetic Process DNA Replication Initiation Cellular Response To Gamma Radiation Site Of Double-strand Break Telomere Maintenance Nucleus Negative Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome PML Body DNA Recombination Alpha DNA Polymerase:primase Complex Glial Cell Apoptotic Process Response To Radiation Regulation Of Cell Cycle Phase Transition Telomere Organization Histone Kinase Activity Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Cell Cycle Process 4 Iron, 4 Sulfur Cluster Binding Double-strand Break Repair Via Homologous Recombination	Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer DNA Replication DNA Replication Initiation Nucleotide-excision Repair DNA-templated DNA Replication DNA Metabolic Process DNA Biosynthetic Process Single-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process Double-strand Break Repair Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Macromolecule Biosynthetic Process Leading Strand Elongation Single-stranded Telomeric DNA Binding Nucleic Acid Metabolic Process DNA Binding G-rich Strand Telomeric DNA Binding DNA Strand Elongation Involved In DNA Replication Chromatin Binding DNA Replication Factor A Complex Lateral Element DNA Polymerase Activity DNA Repair DNA Replication Origin Binding DNA Strand Elongation Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity DNA-directed DNA Polymerase Activity Telomere Maintenance Via Telomerase Protein Localization To Organelle RNA-templated DNA Biosynthetic Process Protein Localization To Site Of Double-strand Break Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Mismatch Repair DNA Damage Response Condensed Chromosome Base-excision Repair Homeostasis Of Number Of Cells Within A Tissue DNA Synthesis Involved In DNA Repair Site Of DNA Damage Condensed Nuclear Chromosome Male Germ Cell Nucleus Double-strand Break Repair Via Nonhomologous End Joining Damaged DNA Binding Nucleoplasm
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