BCL10 and CCDC180

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BCL10	CCDC180
Description		BCL10 immune signaling adaptor	coiled-coil domain containing 180
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Exosome
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	21 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MECOM MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11
Entrez ID		8915	100499483
HPRD ID		04625
Ensembl ID		ENSG00000142867	ENSG00000197816
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	A0A6E1Y6F7 B4DZK1 Q9P1Z9
PDB IDs		2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process	Intracellular Signal Transduction Mismatched DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation ATP-dependent DNA Damage Sensor Activity Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Signal Transduction Negative Regulation Of Cell-matrix Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Somatic Hypermutation Of Immunoglobulin Genes Nucleus Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Multicellular Organismal Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Protein Localization To Nucleus Cell Population Proliferation Chiasma Negative Regulation Of Focal Adhesion Assembly Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Nucleoplasm Cytosol Intracellular Signaling Cassette MutLalpha Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Regulation Of Protein Phosphorylation Positive Regulation Of Isotype Switching Apoptotic Process Negative Regulation Of Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Regulation Of Cell Activation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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