BCL10 and C9orf89

Number of citations of the paper that reports this interaction (PMID 15637807)
2

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		BCL10	C9orf89
Gene Name		B-cell CLL/lymphoma 10	chromosome 9 open reading frame 89
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Plasma Membrane CBM Complex T Cell Receptor Complex Protein Complex Membrane Raft Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm	Nucleus Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Kinase B Binding Protein Self-association NF-kappaB Binding	CARD Domain Binding
	Biological Process	B Cell Apoptotic Process Neural Tube Closure Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Response To Food Positive Regulation Of Mast Cell Cytokine Production Fc-epsilon Receptor Signaling Pathway Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Protein Homooligomerization T Cell Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: AKT1 ATM BIRC3 C9orf89 CARD10 CARD11 CARD14 CARD9 CASP9 CDK9 CHUK IKBKB IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NLRC4 PELI2 PRRG4 RIPK2 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 UBC UBE2N UBE2V2 USHBP1	1 interactors: BCL10
Entrez ID		8915	84270
HPRD ID		04625	12985
Ensembl ID		ENSG00000142867	ENSG00000165233
Uniprot IDs		O95999	Q96LW7
PDB IDs			4DWN 4FH0
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Signaling Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Immune System Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response Positive Regulation Of Immune Response Toll-like Receptor 9 Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Signal Transduction Immune Response Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway	Positive Regulation Of Mast Cell Cytokine Production Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Interleukin-6 Production Positive Regulation Of Interleukin-8 Biosynthetic Process B Cell Apoptotic Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Interleukin-8 Biosynthetic Process T Cell Apoptotic Process Regulation Of B Cell Apoptotic Process Response To Food Cytokine Biosynthetic Process Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cytokine Metabolic Process Positive Regulation Of Interleukin-8 Production Response To Fungus Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Defense Response Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Cytokine Biosynthetic Process Cellular Response To Mechanical Stimulus Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Neural Tube Closure Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Neural Tube Formation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Endopeptidase Activity Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Cytokine Production Activation Of Innate Immune Response Embryonic Epithelial Tube Formation Positive Regulation Of Peptidase Activity Epithelial Tube Formation Tube Formation Morphogenesis Of Embryonic Epithelium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Positive Regulation Of Innate Immune Response
Tagcloud ?		adaptor assembly carma1 cbm clustering clusters connecting cytosolic effector engagement ensure ikappab ikappabalpha ikk incompletely inhibiting kappab malt1 nf p62 recruited requires signalosome signalosomes tak1 tcr transiently translocated triggers
Tagcloud (Difference) ?		adaptor assembly carma1 cbm clustering clusters connecting cytosolic effector engagement ensure ikappab ikappabalpha ikk incompletely inhibiting kappab malt1 nf p62 recruited requires signalosome signalosomes tak1 tcr transiently translocated triggers
Tagcloud (Intersection) ?