BCL10 and MIB2

Number of citations of the paper that reports this interaction (PubMedID 21896478)
47

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		BCL10	MIB2
Description		BCL10 immune signaling adaptor	MIB E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Notch Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)	Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)
Interacting Genes		45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	13 interacting genes: ACTA1 ACTC1 BCL10 CYLD GRIN2B JAG2 SRPK2 TBK1 UBC UBE2D1 UBE2D2 UBE2N UBE2U
Entrez ID		8915	142678
HPRD ID		04625	15905
Ensembl ID		ENSG00000142867	ENSG00000197530
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	A0A8C8N694 A0A8C8USR6 E9PD12 Q96AX9
PDB IDs		2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process	Ubiquitin Conjugating Enzyme Activity ATP Binding Nucleotide Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein Modification Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification TOR Signaling Negative Regulation Of TOR Signaling Protein Polyubiquitination Regulation Of TORC1 Signaling Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of T Cell Receptor Signaling Pathway Protein Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Post-translational Protein Modification Myosin Binding Immune Response-activating Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Proteolysis Defense Response To Symbiont Immune Response-regulating Signaling Pathway Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Regulation Of Protein Ubiquitination Peptidyl-serine Phosphorylation Response To Nutrient Levels Activation Of Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Regulation Of T Cell Receptor Signaling Pathway Sarcomere Cytoplasmic Microtubule
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